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dc.contributor.authorMessinis, I. E.en
dc.contributor.authorLolis, D.en
dc.contributor.authorZikopoulos, K.en
dc.contributor.authorTsahalina, E.en
dc.contributor.authorSeferiadis, K.en
dc.contributor.authorTempleton, A. A.en
dc.rightsDefault Licence-
dc.subjectFollicle Stimulating Hormone/*pharmacologyen
dc.subjectGonadal Hormonesen
dc.subjectGonadotropin-Releasing Hormone/*analogs & derivatives/diagnostic use/metabolismen
dc.subjectLuteinizing Hormone/blood/*secretionen
dc.subjectOvary/drug effects/*metabolism/secretionen
dc.subjectTime Factorsen
dc.titleEffect of an increase in FSH on the production of gonadotrophin-surge-attenuating factor in womenen
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.abstractGonadotrophin-surge-attenuating factor (GnSAF) is a putative nonsteroidal ovarian factor that is produced by FSH and that attenuates the LH surge in superovulated women. To study further the role of FSH in the production of GnSAF, 12 normally ovulating women were divided into two groups and investigated during two cycles: a cycle treated with placebo (control) and a cycle treated with FSH. In group 1 (n = 6), placebo (2 ml 0.9% normal saline) or FSH (450 iu) was injected i.m. on day 2 of the cycle (09:00 h). In group 2 (n = 6), placebo (2 ml 0.9% normal saline) or FSH (225 iu) was injected on the day (09:00 h) on which the dominant follicle was 14-15 mm in diameter, as measured by ultrasound (i.e. after the pituitary had been primed by endogenous oestrogen for several days). The response of LH over 30 min (delta LH) to an injection of 10 micrograms LHRH i.v. (bioassay for GnSAF in vivo) was investigated once a day in group 1, and 4, 8, 12 and 24 h after the injection of placebo or FSH in group 2. In group 1, delta LH was significantly attenuated 12 h after treatment with FSH compared with the control cycles, while serum oestradiol concentrations increased 24 h after the injection of FSH. The decrease in delta LH lasted for the period when the FSH concentration was increased (3 days). A significant decrease in the basal concentration of LH was correlated with the increase in the oestradiol concentration.(ABSTRACT TRUNCATED AT 250 WORDS)en
heal.journalNameJ Reprod Fertilen
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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