Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22235
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dc.contributor.authorSpirou, A.en
dc.contributor.authorRizos, E.en
dc.contributor.authorLiberopoulos, E. N.en
dc.contributor.authorKolaitis, N.en
dc.contributor.authorAchimastos, A.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T19:23:03Z-
dc.date.available2015-11-24T19:23:03Z-
dc.identifier.issn1074-2484-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22235-
dc.rightsDefault Licence-
dc.subject1-Alkyl-2-acetylglycerophosphocholine Esterase/blooden
dc.subjectAgeden
dc.subjectAntihypertensive Agents/pharmacology/*therapeutic useen
dc.subjectAryldialkylphosphatase/blooden
dc.subjectBlood Coagulation/drug effectsen
dc.subjectBlood Glucose/drug effectsen
dc.subjectBlood Pressure/*drug effectsen
dc.subjectCalcium Channel Blockers/pharmacology/*therapeutic useen
dc.subjectElectrolytes/blooden
dc.subjectFemaleen
dc.subjectFibrinolysis/drug effectsen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectHypertension/blood/*drug therapy/physiopathologyen
dc.subjectIsoprostanes/blooden
dc.subjectKidney Function Testsen
dc.subjectLipids/blooden
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNifedipine/*analogs & derivatives/pharmacology/therapeutic useen
dc.subjectOxidative Stress/drug effectsen
dc.subjectPhospholipases A2en
dc.subjectPilot Projectsen
dc.subjectTime Factorsen
dc.subjectTreatment Outcomeen
dc.titleEffect of barnidipine on blood pressure and serum metabolic parameters in patients with essential hypertension: a pilot studyen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1177/1074248406296108-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17220472-
heal.identifier.secondaryhttp://cpt.sagepub.com/content/11/4/256.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2006-
heal.abstractThe effect of barnidipine, a calcium channel blocker, on metabolic parameters is not well known. The authors conducted the present pilot study to evaluate the possible effects of barnidipine on parameters involved in atherogenesis, oxidative stress, and clotting activity. This open-label intervention study included 40 adult patients with essential hypertension who received barnidipine 10 mg once daily. Barnidipine significantly reduced systolic and diastolic blood pressure as well as isoprostane levels, which represent a reliable marker of oxidative stress. In contrast, barnidipine had a neutral effect on lipid profile and apolipoprotein levels, did not influence glucose homeostasis, had no effect on renal function, and did not cause any changes in electrolyte levels. Moreover, barnidipine did not affect either the clotting/fibrinolytic status (evaluated by measurement of fibrinogen, total plasminogen activator inhibitor, tissue plasminogen activator, and a2 antiplasmin) or the enzymatic activity of the inflammatory/anti-inflammatory mediators lipoprotein-associated phospholipase A2 and paraoxonase 1, respectively. Barnidipine should be mainly considered as an antihypertensive agent with neutral effects on most of the studied metabolic parameters in hypertensive patients. Any antioxidant effect of barnidipine needs further investigation.en
heal.journalNameJ Cardiovasc Pharmacol Theren
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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