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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Contopoulos-Ioannidis, D. G. | en |
| dc.contributor.author | O'Brien, T. R. | en |
| dc.contributor.author | Goedert, J. J. | en |
| dc.contributor.author | Rosenberg, P. S. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T19:23:02Z | - |
| dc.date.available | 2015-11-24T19:23:02Z | - |
| dc.identifier.issn | 1525-4135 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22232 | - |
| dc.rights | Default Licence | - |
| dc.subject | Continental Population Groups/genetics | en |
| dc.subject | Europe/ethnology | en |
| dc.subject | Female | en |
| dc.subject | HIV Infections/ethnology/*genetics/*transmission | en |
| dc.subject | HIV-1/physiology | en |
| dc.subject | *Heterozygote | en |
| dc.subject | Homozygote | en |
| dc.subject | Humans | en |
| dc.subject | Infant, Newborn | en |
| dc.subject | *Infectious Disease Transmission, Vertical | en |
| dc.subject | Male | en |
| dc.subject | Polymorphism, Genetic/genetics | en |
| dc.subject | Pregnancy | en |
| dc.subject | Receptors, CCR5/*genetics | en |
| dc.subject | Risk Factors | en |
| dc.title | Effect of CCR5-delta32 heterozygosity on the risk of perinatal HIV-1 infection: a meta-analysis | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/12514416 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2003 | - |
| heal.abstract | Several studies have investigated whether heterozygosity for a 32-basepair deletion in the CC chemokine receptor 5 gene (CCR5-Delta32 ) affects susceptibility to perinatal HIV-1 infection, but results have been inconclusive. We performed a meta-analysis of published data from 11 studies of HIV-1 perinatally exposed children who were genotyped for the CCR5-Delta32 polymorphism. The crude overall HIV-1 infection rates, by simple data pooling, were 20% (one of five) amongCCR5-Delta32 homozygote children, 39% (131 of 335) among CCR5-Delta32 heterozygote children, and 40% (1408 of 3526) among wild-type CCR5 homozygote children. Compared with wild-type homozygotes, the random effects risk ratio for heterozygotes was 1.04 (95% confidence interval [CI], 0.92-1.17) among all children (N = 3861) and 1.03 (95% CI, 0.90-1.17) among those of European descent (n = 2890). Results were similar when adjusted for the available data on the CCR2-641 polymorphism (n = 1542). The meta-analysis clarifies that perinatal infection is not significantly altered by heterozygosity for CCR5-Delta32 in the child. | en |
| heal.journalName | J Acquir Immune Defic Syndr | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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