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  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22221
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dc.contributor.authorMusey, P. I.en
dc.contributor.authorAdlercreutz, H.en
dc.contributor.authorGould, K. G.en
dc.contributor.authorCollins, D. C.en
dc.contributor.authorFotsis, T.en
dc.contributor.authorBannwart, C.en
dc.contributor.authorMakela, T.en
dc.contributor.authorWahala, K.en
dc.contributor.authorBrunow, G.en
dc.contributor.authorHase, T.en
dc.date.accessioned2015-11-24T19:22:59Z-
dc.date.available2015-11-24T19:22:59Z-
dc.identifier.issn0024-3205-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22221-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectChromatography, Gasen
dc.subjectChromatography, High Pressure Liquiden
dc.subject*Dieten
dc.subjectEstrogens, Non-Steroidal/*metabolism/urineen
dc.subject*Isoflavonesen
dc.subjectLignans/*metabolism/urineen
dc.subjectMaleen
dc.subjectPan troglodytesen
dc.subjectPhytoestrogensen
dc.subjectPlant Preparationsen
dc.subjectPlants/metabolismen
dc.titleEffect of diet on lignans and isoflavonoid phytoestrogens in chimpanzeesen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7637537-
heal.identifier.secondaryhttp://ac.els-cdn.com/002432059500317Y/1-s2.0-002432059500317Y-main.pdf?_tid=4b517aa9b82e031f86e1f399e895b62d&acdnat=1332753193_d251f5bafa879036d415648add7bc866-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1995-
heal.abstractDiphenolic compounds belonging to the classes of lignans and isoflavonoids have been identified in urine of man and animals, including the chimpanzee. Some of these compounds, formed by intestinal bacteria from plant lignans and phytoestrogens, have been shown in animal studies to exhibit biological activities that suggest they could function as cancer-protective compounds. The effect of diet on urinary excretion of these compounds in the adult male chimpanzee has been studied. It was found that the chimpanzees consuming their regular food excreted large amounts of the isoflavonoid phytoestrogens, equol (mean +/- SE) (127.5 +/- 34.0 nmol/mg cr.) and daidzein (20.7 +/- 9.0 nmol/mg cr.) and the lignan, enterolactone (14.1 + 3.5 nmol/mg cr.). Small amounts of the lignan, enterodiol, (0.4 +/- 0.2 nmol/mg cr.) were also excreted. On all other four test diets (high protein, high carbohydrate, high vegetable, and high fat), the excretion was less, particularly on a high fat diet where the excretion of all diphenolic compounds was reduced by more than 90% to a level observed in omnivorous human subjects or women with breast cancer. These results suggest that diet profoundly influences the excretion of both animal lignans and phytoestrogens in urine. Because non-human primates are particularly resistant to mammary and genital carcinoma on estrogen treatment, the present data suggest that the very high levels of phytoestrogens and lignans as found during exposure to the regular diet may partially account for why these primates are so resistant to hormonal manipulations to induce cancer.en
heal.journalNameLife Scien
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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