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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Katsanos, K. H. | en |
| dc.contributor.author | Tzambouras, N. | en |
| dc.contributor.author | Baltayiannis, G. | en |
| dc.contributor.author | Kondodimou, K. | en |
| dc.contributor.author | Kolios, G. | en |
| dc.contributor.author | Christodoulou, D. | en |
| dc.contributor.author | Katsaraki, A. | en |
| dc.contributor.author | Kitsanou, M. | en |
| dc.contributor.author | Seferiadis, K. | en |
| dc.contributor.author | Tsianos, E. V. | en |
| dc.date.accessioned | 2015-11-24T19:22:56Z | - |
| dc.date.available | 2015-11-24T19:22:56Z | - |
| dc.identifier.issn | 1879-0828 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22209 | - |
| dc.rights | Default Licence | - |
| dc.title | The true value of serum elastase-1 in endoscopic retrograde cholangiopancreatography (ERCP) | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/12144913 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2002 | - |
| heal.abstract | BACKGROUND: The routine use of serum elastase-1 in patients, pre- and post-endoscopic retrograde cholangiopancreatography (ERCP), has been strongly supported but not sufficiently correlated with diagnosis, patient outcome/prognosis, or routine markers such as serum amylase. The value of serum elastase-1 post-ERCP, as far as clinical diagnosis and prognosis is concerned, was tested and compared with serum amylase in terms of sensitivity, specificity, positive prognostic value (PPV), and negative prognostic value (NPV). METHODS: In a prospective study of 38 consecutive patients undergoing ERCP, we assessed the following biochemical parameters 24 h before ERCP and 2 and 18 h after ERCP: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (gamma-GT), alkaline phosphatase (ALP), amylase (AMS), lactate dehydrogenase (LDH), and pancreatic elastase-1. RESULTS: Statistically significant changes were found between pre-ERCP and 18-h post-ERCP in elastase-1 (P=0.009), amylase (P=0.016), gamma-GT (P=0.04), and ALP (P=0.04). Changes between 2-h and 18-h post-ERCP in all parameters tested were not statistically significant. No statistical significance was found between any biochemical parameter and specific ERCP diagnosis. CONCLUSIONS: This study showed that 2-h post-ERCP serum elastase-1 was 100% specific for post-ERCP pancreatitis or other underlying severe pathology while, at the same time, amylase was only 50% specific. The specificity of serum elastase-1 still remained high (87.5%) 18-h post-ERCP, while amylase only had a specificity of 25% at that time. In contrast, amylase had a sensitivity of 83.3 and 90% in the 2-h and 18-h post-ERCP serum samples, while elastase-1 only had a sensitivity of 56.7 and 73.3%, respectively. | en |
| heal.journalName | Eur J Intern Med | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Seferiadis-2002-the true value.pdf | 156.2 kB | Adobe PDF | View/Open Request a copy |
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