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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22194
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dc.contributor.authorElisaf, M. S.en
dc.contributor.authorBairaktari, E. T.en
dc.contributor.authorNicolaides, C.en
dc.contributor.authorKakaidi, B.en
dc.contributor.authorTzallas, C. S.en
dc.contributor.authorKatsaraki, A.en
dc.contributor.authorPavlidis, N. A.en
dc.date.accessioned2015-11-24T19:22:51Z-
dc.date.available2015-11-24T19:22:51Z-
dc.identifier.issn0959-8049-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22194-
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAntineoplastic Agents/*adverse effectsen
dc.subjectApolipoprotein A-I/blooden
dc.subjectApolipoproteins B/blooden
dc.subjectApolipoproteins E/blooden
dc.subjectBreast Neoplasms/blood/*drug therapyen
dc.subjectCholesterol, HDL/blooden
dc.subjectCholesterol, LDL/blooden
dc.subjectEnzyme Inhibitors/*adverse effectsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLipids/*blooden
dc.subjectLipoprotein(a)/blooden
dc.subjectMiddle Ageden
dc.subjectNitriles/*adverse effectsen
dc.subjectPostmenopause/*blooden
dc.subjectRisk Factorsen
dc.subjectTriazoles/*adverse effectsen
dc.subjectTriglycerides/blooden
dc.titleEffect of letrozole on the lipid profile in postmenopausal women with breast canceren
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11506958-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0959804901001551/1-s2.0-S0959804901001551-main.pdf?_tid=af73e4e734f63bc0886fbb8f9586b3e9&acdnat=1333611149_9efc2a6d09ced7930dec9ff3ecf02937-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2001-
heal.abstractHormonal therapy plays a central role in the overall treatment of breast cancer. Aromatase inhibitors can inhibit the aromatase enzyme system resulting in a reduction of oestrogens. Letrozole is a non-steroidal aromatase inhibitor that effectively blocks aromatase activity without interfering with adrenal steroid biosynthesis. The drug can significantly reduce the levels of plasma oestrogens, which remain suppressed throughout the treatment. Data are scarce concerning the influence of these drugs on serum lipid levels. In the present study, we evaluated the effects of letrozole on the serum lipid profile in postmenopausal women with breast cancer. A total of 20 patients with breast cancer were treated with letrozole, 2.5 mg once daily. After an overnight fast, serum lipid parameters (total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides, apolipoproteins A1, B and E and lipoprotein (a)) were measured before treatment and at 8 and 16 weeks afterwards. A significant increase in total cholesterol (P=0.05), LDL cholesterol (P<0.01) and apolipoprotein B levels (P=0.05) in the serum, as well as in the atherogenic risk ratios total cholesterol/HDL cholesterol (P<0.005) and LDL cholesterol/HDL cholesterol (P<0.005) was noticed after letrozole treatment. We conclude that letrozole administration in postmenopausal women with breast cancer has an unfavourable effect on the serum lipid profile.en
heal.journalNameEur J Canceren
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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