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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22186
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dc.contributor.authorAthyros, V. G.en
dc.contributor.authorMikhailidis, D. P.en
dc.contributor.authorDidangelos, T. P.en
dc.contributor.authorGiouleme, O. I.en
dc.contributor.authorLiberopoulos, E. N.en
dc.contributor.authorKaragiannis, A.en
dc.contributor.authorKakafika, A. I.en
dc.contributor.authorTziomalos, K.en
dc.contributor.authorBurroughs, A. K.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T19:22:46Z-
dc.date.available2015-11-24T19:22:46Z-
dc.identifier.issn0300-7995-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22186-
dc.rightsDefault Licence-
dc.subjectAnti-Obesity Agents/therapeutic useen
dc.subjectDiet, Fat-Restricteden
dc.subjectDrug Therapy, Combinationen
dc.subjectDyslipidemias/drug therapyen
dc.subjectFatty Liver/*drug therapy/etiology/ultrasonographyen
dc.subjectFemaleen
dc.subjectFenofibrate/*therapeutic useen
dc.subjectHeptanoic Acids/*therapeutic useen
dc.subjectHumansen
dc.subjectHypolipidemic Agents/*therapeutic useen
dc.subjectLactones/therapeutic useen
dc.subjectMaleen
dc.subjectMetabolic Syndrome X/*drug therapy/physiopathologyen
dc.subjectMiddle Ageden
dc.subjectPrevalenceen
dc.subjectProspective Studiesen
dc.subjectPyrroles/*therapeutic useen
dc.subjectRisk Factorsen
dc.subjectTreatment Outcomeen
dc.subjectWeight Lossen
dc.titleEffect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrome: a randomised studyen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1185/030079906X104696-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16709309-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.1185/030079906X104696-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2006-
heal.abstractBACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome (MetS). There is no established treatment for NAFLD. AIM: To evaluate a multifactorial intervention in the treatment of NAFLD. METHODS: A prospective, open-label, randomised study in non-diabetic patients (n = 186) with MetS (follow-up: 54 weeks). All patients had both biochemical and ultrasonographic evidence of NAFLD at baseline. Other causes of liver disease were excluded. Patients received lifestyle advice and treatment for hypertension (mainly inhibitors of the renin-angiotensin system), impaired fasting glucose (metformin), obesity (orlistat) and dyslipidaemia [randomly allocated to atorvastatin 20 mg/day (n = 63) or micronised fenofibrate 200 mg/day (n = 62) or both drugs (n = 61)]. Liver ultrasonography was assessed at baseline and at the end of the study. RESULTS: At the end of treatment, 67% of patients on atorvastatin, 42% on fenofibrate and 70% on combination treatment no longer had biochemical plus ultrasonographic evidence of NAFLD (p < 0.05 vs. baseline for all comparisons). The percentage of patients who no longer had evidence of NAFLD was significantly higher (p < 0.009) in the atorvastatin and combination groups compared with the fenofibrate group. This effect was independently related to drug treatment, as well as to reductions in high-sensitivity C-reactive protein, waist circumference, body weight, triglycerides, low-density lipoprotein-cholesterol, total cholesterol, systolic blood pressure and glucose. Four patients discontinued treatment because of adverse effects. CONCLUSIONS: Multifactorial intervention in MetS patients with both biochemical and ultrasonographic evidence of NAFLD offsets surrogate markers of NAFLD (i.e. elevated aminotransferase plus echogenic liver).en
heal.journalNameCurrent Medical Research and Opinionen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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