Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22144
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dc.contributor.authorDrosos, A. A.en
dc.contributor.authorMoutsopoulos, N. M.en
dc.date.accessioned2015-11-24T19:22:06Z-
dc.date.available2015-11-24T19:22:06Z-
dc.identifier.issn0040-3660-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22144-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectClinical Trials as Topicen
dc.subjectCyclosporins/adverse effects/*therapeutic useen
dc.subjectDouble-Blind Methoden
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectSalivary Glands/drug effects/secretionen
dc.subjectSalivation/drug effectsen
dc.subjectSjogren's Syndrome/drug therapyen
dc.subjectXerophthalmia/drug therapyen
dc.subjectXerostomia/drug therapyen
dc.titleEffectiveness and safety of using cyclosporin A in the treatment of primary Sjogren's syndromeen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/3293257-
heal.languageru-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1988-
heal.abstractWe used oral cyclosporine-A (CyA) (5 mg/kg/day) initially in a double blind study for 6 mos. 10 patients received CyA and 10 placebo. At the end of this study it was observed that CyA improved subjective xerostomia, while subjective xerophthalmia, parotid gland enlargement, Schirmer-I-test and parotid flow rate did not show any significant differences in the two study groups. 9 of 10 patients who had received CyA for 6 mos and 9 of 10 in the placebo group continued in an open trial (CyA at the same dose) for an additional 6 mos. At the end of the study the only efficacy of CyA observed was improvement of subjective xerostomia. The side-effects observed were hypertrichosis (14 persons), mild hypertension (4), infections (5) and 3 dropped out because of nausea, tremor, paresthesias and infections. In conclusion, small doses of CyA for 12 mos are rather ineffective for Sjogren's syndrome.en
heal.journalNameTer Arkhen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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