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DC Field | Value | Language |
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dc.contributor.author | Stoychkov, J. N. | en |
dc.contributor.author | Schultz, R. M. | en |
dc.contributor.author | Chirigos, M. A. | en |
dc.contributor.author | Pavlidis, N. A. | en |
dc.contributor.author | Goldin, A. | en |
dc.date.accessioned | 2015-11-24T19:21:51Z | - |
dc.date.available | 2015-11-24T19:21:51Z | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22127 | - |
dc.rights | Default Licence | - |
dc.subject | Animals | en |
dc.subject | BCG Vaccine/pharmacology | en |
dc.subject | Cyclophosphamide/*administration & dosage | en |
dc.subject | Cytotoxicity, Immunologic/*drug effects | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Doxorubicin/*administration & dosage | en |
dc.subject | Macrophages/*drug effects/immunology | en |
dc.subject | Male | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred Strains | en |
dc.subject | Pyran Copolymer/pharmacology | en |
dc.subject | Time Factors | en |
dc.title | Effects of adriamycin and cyclophosphamide treatment on induction of macrophage cytotoxic function in mice | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/455286 | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
heal.publicationDate | 1979 | - |
heal.abstract | The effects of i.p. and s.c. Adriamycin and cyclophosphamide treatment of BALB/c x DBA/2F1 mice were studied alone and in combination with immunotherapeutic agents, pyran copolymer and Bacillus Calmette-Guerin, on macrophage cytotoxic ability, As assessed by direct viable cell counts of MBL-2 leukemia cells, both Adriamycin and cyclophosphamide produced growth-inhibitory macrophages. This function after s.c. cytostatic treatment peaked at Day 1 and decreased progressively, attaining normal control values by Day 6. When adjuvants, such as pyran and B. Calmette-Guerin, were administered i.p. simultaneously with s.c. Adriamycin or cyclophosphamide, adjuvant-induced cytotoxic function was not markedly affected. A better knowledge of the influence of cytostatic agents alone or combined with immunoadjuvants on macrophage cytotoxic ability may be useful in designing more effective chemoimmunotherapy protocols. | en |
heal.journalName | Cancer Res | en |
heal.journalType | peer-reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ |
Files in This Item:
File | Description | Size | Format | |
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Pavlidis-1979-effects of adriamycin.pdf | 836.75 kB | Adobe PDF | View/Open Request a copy |
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