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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kosmidou, M. S. | en |
| dc.contributor.author | Hatzitolios, A. I. | en |
| dc.contributor.author | Adamidou, A. | en |
| dc.contributor.author | Giannopoulos, S. | en |
| dc.contributor.author | Raikos, N. | en |
| dc.contributor.author | Parharidis, G. | en |
| dc.contributor.author | Milionis, H. J. | en |
| dc.date.accessioned | 2015-11-24T19:21:48Z | - |
| dc.date.available | 2015-11-24T19:21:48Z | - |
| dc.identifier.issn | 0895-7061 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22123 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Anticholesteremic Agents/*pharmacology/therapeutic use | en |
| dc.subject | Biological Transport/drug effects | en |
| dc.subject | Blood Pressure/drug effects | en |
| dc.subject | Cholesterol/blood | en |
| dc.subject | Dose-Response Relationship, Drug | en |
| dc.subject | Erythrocytes/*metabolism/pathology | en |
| dc.subject | Female | en |
| dc.subject | Heptanoic Acids/*pharmacology/therapeutic use | en |
| dc.subject | Humans | en |
| dc.subject | Hyperlipidemias/drug therapy/*metabolism/pathology | en |
| dc.subject | Hypertension/*metabolism/pathology | en |
| dc.subject | Insulin Resistance | en |
| dc.subject | Linear Models | en |
| dc.subject | Lithium/*metabolism | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Pyrroles/*pharmacology/therapeutic use | en |
| dc.subject | Sodium/*metabolism | en |
| dc.subject | Triglycerides/blood | en |
| dc.title | Effects of atorvastatin on red-blood cell Na(+)/Li(+) countertransport in hyperlipidemic patients with and without hypertension | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1038/ajh.2007.61 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/18202666 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2008 | - |
| heal.abstract | BACKGROUND: To explore the effect of short-term cholesterol-lowering treatment with atorvastatin on erythrocyte sodium-lithium countertransport (Na(+)/Li(+) CT) activity. METHODS: Group A consisted of 30 patients (14 men) with mild essential hypertension (systolic blood pressure (SBP), 140-159 mm Hg and/or diastolic BP, 90-99 mm Hg) and primary hypercholesterolemia low-density lipoprotein (LDL) cholesterol >4.1 mmol/l and triglycerides (TG) <2.8 mmol/l), group B of 30 normotensive patients (16 men) with primary hypercholesterolemia, while 37 (18 men) healthy volunteers comprised the control group. After a 6-week dietary lead-in, all eligible patients were prescribed 20 mg/day of atorvastatin. Anthropometric data, blood-pressure (BP) measurements and determinations of lipid, non-lipid metabolic parameters (including homeostasis model assessment index, (HOMA-IR)) and erythrocyte Na(+)/Li(+) CT activity were collected at baseline and after 12 weeks of treatment. RESULTS: At baseline Na(+)/Li(+) CT activity was significantly higher in group A and B compared with the control group and correlated directly with obesity indices, systolic and diastolic BP, total cholesterol, LDL-cholesterol, TG, apolipoprotein B (apoB), HOMA-IR, uric acid and inversely with high-density lipoprotein (HDL)-cholesterol and apoA1. Systolic and diastolic BP levels, HOMA-IR and Na(+)/Li(+) CT activity were significantly decreased after atorvastatin treatment in both patient groups. The reduction in Na(+)/Li(+) CT activity correlated with baseline Na(+)/Li(+) CT activity and the changes in HOMA-IR values. CONCLUSIONS: Short-term treatment with atorvastatin for patients with hypercholesterolemia, and with or without essential hypertension, is associated with a significant reduction in the erythrocyte Na(+)/Li(+) CT activity, BP levels and insulin resistance independent of concomitant changes in lipid parameters. | en |
| heal.journalName | Am J Hypertens | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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