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  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22115
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dc.contributor.authorMulherin, S. A.en
dc.contributor.authorO'Brien, T. R.en
dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorGoedert, J. J.en
dc.contributor.authorBuchbinder, S. P.en
dc.contributor.authorCoutinho, R. A.en
dc.contributor.authorJamieson, B. D.en
dc.contributor.authorMeyer, L.en
dc.contributor.authorMichael, N. L.en
dc.contributor.authorPantaleo, G.en
dc.contributor.authorRizzardi, G. P.en
dc.contributor.authorSchuitemaker, H.en
dc.contributor.authorSheppard, H. W.en
dc.contributor.authorTheodorou, I. D.en
dc.contributor.authorVlahov, D.en
dc.contributor.authorRosenberg, P. S.en
dc.date.accessioned2015-11-24T19:21:39Z-
dc.date.available2015-11-24T19:21:39Z-
dc.identifier.issn0269-9370-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22115-
dc.rightsDefault Licence-
dc.subjectAcquired Immunodeficiency Syndrome/*geneticsen
dc.subjectDisease Progressionen
dc.subjectHIV Seropositivity/geneticsen
dc.subjectHIV-1/*geneticsen
dc.subjectHeterozygoteen
dc.subjectHumansen
dc.subjectPolymorphism, Genetic/geneticsen
dc.subjectProportional Hazards Modelsen
dc.subjectReceptors, CCR2en
dc.subjectReceptors, CCR5/*geneticsen
dc.subjectReceptors, Chemokine/*geneticsen
dc.subjectSurvival Analysisen
dc.subjectTime Factorsen
dc.titleEffects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infectionen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1097/01.aids.0000050783.28043.3e-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12556692-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2003-
heal.abstractOBJECTIVE: To examine temporal variation in the effects of CCR5-Delta32 and CCR2-64I chemokine receptor gene polymorphisms on HIV-1 disease progression. DESIGN: Pooled analysis of individual patient data from 10 cohorts of HIV-1 seroconverters from the United States, Europe, and Australia. METHODS: We studied HIV-1 seroconverters of European (n = 1635) or African (n = 215) ancestry who had been genotyped for CCR5-Delta32 and CCR2-64I. We used Cox proportional hazards models with time-varying coefficients to determine whether the genetic protection against AIDS (1987 case definition) and death varied with time since seroconversion. RESULTS: Protection against AIDS conferred by CCR5-Delta32 held constant at a 31% (RH 0.69, 95% CI 0.54, 0.88) reduction in risk over the course of HIV-1 infection, whereas protection against death held constant at a 39% reduction in risk (RH 0.61, 95% CI 0.45, 0.88). When the period from AIDS to death was isolated, the survival benefit of CCR5-Delta32 diminished 2 years after AIDS. Protection against AIDS conferred by CCR2-64I was greatest early in the disease course. Compared with individuals without CCR5-Delta32 or CCR2-64I, individuals with one or two copies of CCR2-64I had a 58% lower risk of AIDS during the first 4 years after seroconversion (RH 0.42, 95% CI 0.23, 0.76), a 19% lower risk during the subsequent 4 years (RH 0.81, 95% CI 0.59, 1.12), and no significant protection thereafter. CONCLUSION: The protection against AIDS provided by CCR5-Delta32 is continuous during the course of infection. In contrast, the protection provided by CCR2-64I is greatest early in the course of infection.en
heal.journalNameAIDSen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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