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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22100
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dc.contributor.authorKondomerkos, D. J.en
dc.contributor.authorKalamidas, S. A.en
dc.contributor.authorKotoulas, O. B.en
dc.date.accessioned2015-11-24T19:21:25Z-
dc.date.available2015-11-24T19:21:25Z-
dc.identifier.issn0263-6484-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22100-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAutacoids/*metabolismen
dc.subjectCyclic AMP/*metabolismen
dc.subjectCyclic AMP-Dependent Protein Kinases/metabolismen
dc.subjectDinoprostone/metabolismen
dc.subjectDopamine/metabolism/pharmacologyen
dc.subjectEpinephrine/metabolism/pharmacologyen
dc.subjectFemaleen
dc.subjectHormones/metabolismen
dc.subjectKupffer Cells/drug effects/metabolismen
dc.subjectLipopolysaccharides/*pharmacologyen
dc.subject*Macrophage Activation/drug effectsen
dc.subjectMacrophages, Alveolar/drug effects/*metabolismen
dc.subjectMacrophages, Peritoneal/drug effects/*metabolism/ultrastructureen
dc.subjectMaleen
dc.subjectNitric Oxide/metabolismen
dc.subjectProstaglandin-Endoperoxide Synthases/metabolismen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.titleEffects of cyclic AMP-elevating hormones and autacoids on LPS-activated rat peritoneal, bronchoalveolar and hepatic (Kupffer) macrophagesen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1002/cbf.1205-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15655807-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/cbf.1205/asset/1205_ftp.pdf?v=1&t=h1ym2ubx&s=95b04e818d9d7b365a7e5ccc087a553190313540-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2006-
heal.abstractPeritoneal, bronchoalveolar and hepatic (Kupffer) macrophages activated in vitro by endotoxin, exhibit alterations in nitric oxide production when certain hormones or other biologically active agents (autacoids) are present in the culture medium. They also show changes in acid beta-glucuronidase activities and morphological changes concerning cell size and general appearance. Agents known to elevate the intracellular levels of cyclic AMP, e.g. adrenalin, prostaglandin E2 and dopamine, increase the nitric oxide production in all three types of macrophage. The addition of H-89, an inhibitor of protein kinase A, abolishes the increase in nitric oxide production. Adrenalin also increases the extracellular activity of beta-glucuronidase. The results of this work suggest that cyclic AMP-elevating hormones and autacoids affect the functions of endotoxin-activated macrophages, such as the production of nitric oxide and the activity of acid beta-glucuronidase.en
heal.journalNameCell Biochem Functen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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