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https://olympias.lib.uoi.gr/jspui/handle/123456789/22096Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kolettis, T. M. | en |
| dc.contributor.author | Baltogiannis, G. G. | en |
| dc.contributor.author | Tsalikakis, D. G. | en |
| dc.contributor.author | Tzallas, A. T. | en |
| dc.contributor.author | Agelaki, M. G. | en |
| dc.contributor.author | Fotopoulos, A. | en |
| dc.contributor.author | Fotiadis, D. I. | en |
| dc.contributor.author | Kyriakides, Z. S. | en |
| dc.date.accessioned | 2015-11-24T19:21:21Z | - |
| dc.date.available | 2015-11-24T19:21:21Z | - |
| dc.identifier.issn | 0014-2999 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22096 | - |
| dc.rights | Default Licence | - |
| dc.subject | Action Potentials/drug effects | en |
| dc.subject | Animals | en |
| dc.subject | Antihypertensive Agents/*pharmacology | en |
| dc.subject | Electrocardiography | en |
| dc.subject | Epinephrine/metabolism | en |
| dc.subject | Myocardial Infarction/complications/*drug therapy | en |
| dc.subject | Norepinephrine/metabolism | en |
| dc.subject | Random Allocation | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Receptor, Endothelin A/*antagonists & inhibitors | en |
| dc.subject | Receptor, Endothelin B/*antagonists & inhibitors | en |
| dc.subject | Sulfonamides/*pharmacology | en |
| dc.subject | Sympathetic Nervous System/drug effects/metabolism | en |
| dc.subject | Tachycardia, Ventricular/*drug therapy/etiology | en |
| dc.subject | Telemetry | en |
| dc.subject | Ventricular Fibrillation/drug therapy/etiology | en |
| dc.title | Effects of dual endothelin receptor blockade on sympathetic activation and arrhythmogenesis during acute myocardial infarction in rats | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1016/j.ejphar.2007.11.002 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/18048027 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S001429990701240X/1-s2.0-S001429990701240X-main.pdf?_tid=4c519ae22d585db545eee9c74b2ce7fe&acdnat=1333699152_3c7f86d4c556abc8e5a855a7a7eb045f | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2008 | - |
| heal.abstract | The effects of dual (ETA and ETB) endothelin receptor blockade on ventricular arrhythmogenesis during acute myocardial infarction are not well defined. We randomly allocated Wistar rats to bosentan (100 mg/kg daily, n=24), a dual endothelin receptor antagonist, or vehicle (n=23). After 7 days of treatment, myocardial infarction was induced by permanent coronary ligation. Ventricular tachyarrhythmias were evaluated for 24 h following ligation, using a miniature telemetry electrocardiogram recorder. Action potential duration was measured from monophasic epicardial recordings and sympathetic activation was assessed by heart rate variability and catecholamine serum level measurements. Compared to controls (1012+/-185 s), bosentan (59+/-24 s) markedly decreased (P<0.00001) the total duration of ventricular tachyarrhythmias during the delayed (1-24 h) phase post-ligation, with a modest effect during the early (0-1 h) phase (132+/-38 s, versus 43+/-18 s, respectively, P=0.053). Treatment did not affect infarct size or total mortality. Action potential duration at 90% repolarization prolonged in controls (from 93.1+/-4.7 ms to 117.6+/-6.9 ms), displaying increased temporal dispersion (from 4.14+/-0.45 ms to 10.42+/-2.51 ms, both P<0.001), but was preserved in treated animals. Bosentan decreased norepinephrine, but increased epinephrine levels 24 h post-ligation. Low frequency spectra of heart rate variability, an index of net sympathetic tone, were lower in bosentan-treated rats. Dual endothelin-1 receptor blockade decreases ventricular tachyarrhythmias during myocardial infarction without reperfusion, by preventing repolarization inhomogeneity. Diverse treatment effects on sympathetic activation may ameliorate the antiarrhythmic action. | en |
| heal.journalName | European Journal of Pharmacology | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kolettis-2008-Effects of dual endo.pdf | 387.19 kB | Adobe PDF | View/Open Request a copy |
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