Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/22066Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Hernandez, A. V. | en |
| dc.contributor.author | Westerhout, C. M. | en |
| dc.contributor.author | Steyerberg, E. W. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.contributor.author | Bueno, H. | en |
| dc.contributor.author | White, H. | en |
| dc.contributor.author | Theroux, P. | en |
| dc.contributor.author | Moliterno, D. J. | en |
| dc.contributor.author | Armstrong, P. W. | en |
| dc.contributor.author | Califf, R. M. | en |
| dc.contributor.author | Wallentin, L. C. | en |
| dc.contributor.author | Simoons, M. L. | en |
| dc.contributor.author | Boersma, E. | en |
| dc.date.accessioned | 2015-11-24T19:20:50Z | - |
| dc.date.available | 2015-11-24T19:20:50Z | - |
| dc.identifier.issn | 1468-201X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22066 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Age Factors | en |
| dc.subject | Aged | en |
| dc.subject | Aged, 80 and over | en |
| dc.subject | Clinical Trials as Topic | en |
| dc.subject | Female | en |
| dc.subject | Hemorrhage/etiology/mortality | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Myocardial Infarction/*drug therapy/mortality | en |
| dc.subject | Platelet Glycoprotein GPIIb-IIIa Complex/*antagonists & inhibitors | en |
| dc.subject | Treatment Outcome | en |
| dc.title | Effects of platelet glycoprotein IIb/IIIa receptor blockers in non-ST segment elevation acute coronary syndromes: benefit and harm in different age subgroups | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1136/hrt.2006.098657 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17065179 | - |
| heal.identifier.secondary | http://heart.bmj.com/content/93/4/450 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2007 | - |
| heal.abstract | OBJECTIVE: To investigate whether the beneficial and harmful effects of platelet glycoprotein IIb/IIIa receptor blockers in non-ST elevation acute coronary syndromes (NSTE-ACS) depend on age. METHODS: A meta-analysis of six trials of platelet glycoprotein IIb/IIIa receptor blockers in patients with NSTE-ACS (PRISM, PRISM-PLUS, PARAGON-A, PURSUIT, PARAGON-B, GUSTO IV-ACS; n = 31 402) was performed. We applied multivariable logistic regression analyses to evaluate the drug effects on death or non-fatal myocardial infarction at 30 days, and on major bleeding, by age subgroups (<60, 60-69, 70-79, > or =80 years). We quantified the reduction of death or myocardial infarction as the number needed to treat (NNT), and the increase of major bleeding as the number needed to harm (NNH). RESULTS: Subgroups had 11 155 (35%), 9727 (31%), 8468 (27%) and 2049 (7%) patients, respectively. The relative benefit of platelet glycoprotein IIb/IIIa receptor blockers did not differ significantly (p = 0.5) between age subgroups (OR (95% CI) for death or myocardial infarction: 0.86 (0.74 to 0.99), 0.90 (0.80 to 1.02), 0.97 (0.86 to 1.10), 0.90 (0.73 to 1.16); overall 0.91 (0.86 to 0.99). ORs for major bleeding were 1.9 (1.3 to 2.8), 1.9 (1.4 to 2.7), 1.6 (1.2 to 2.1) and 2.5 (1.5-4.1). Overall NNT was 105, and overall NNH was 90. The oldest patients had larger absolute increases in major bleeding, but also had the largest absolute reductions of death or myocardial infarction. Patients > or =80 years had half of the NNT and a third of the NNH of patients <60 years. CONCLUSIONS: In patients with NSTE-ACS, the relative reduction of death or non-fatal myocardial infarction with platelet glycoprotein IIb/IIIa receptor blockers was independent of patient age. Larger absolute outcome reductions were seen in older patients, but with a higher risk of major bleeding. Close monitoring of these patients is warranted. | en |
| heal.journalName | Heart | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
There are no files associated with this item.
This item is licensed under a Creative Commons License
