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  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/22063
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dc.contributor.authorDimitriadis, F.en
dc.contributor.authorGiannakis, D.en
dc.contributor.authorPardalidis, N.en
dc.contributor.authorTsoukanelis, K.en
dc.contributor.authorKanakas, N.en
dc.contributor.authorSaito, M.en
dc.contributor.authorWatanabe, T.en
dc.contributor.authorMiyagawa, I.en
dc.contributor.authorTsounapi, P.en
dc.contributor.authorSofikitis, N.en
dc.date.accessioned2015-11-24T19:20:47Z-
dc.date.available2015-11-24T19:20:47Z-
dc.identifier.issn1439-0272-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22063-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectBody Temperatureen
dc.subject*DNA Damageen
dc.subjectDeoxyguanosine/analogs & derivatives/analysisen
dc.subject*Embryonic Developmenten
dc.subjectEpididymis/anatomy & histologyen
dc.subjectFertilization in Vitroen
dc.subject*Fetal Developmenten
dc.subjectMaleen
dc.subjectOrgan Sizeen
dc.subjectRatsen
dc.subjectSeminal Vesicles/anatomy & histologyen
dc.subjectSperm Counten
dc.subjectSperm Motilityen
dc.subjectSpermatozoa/chemistry/*pathologyen
dc.subjectTestis/anatomy & histology/*blood supply/*injuries/surgeryen
dc.subjectTestosterone/blooden
dc.subjectVeinsen
dc.titleEffects of primary testicular damage on sperm DNA oxidative status and embryonic and foetal developmenten
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1111/j.1439-0272.2009.00929.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19737276-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1439-0272.2009.00929.x/asset/j.1439-0272.2009.00929.x.pdf?v=1&t=h0p8a4uc&s=316ff8130d1b9ef19297d740c074c35049bc9456-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2009-
heal.abstractWe evaluated the development of embryos generated from the fertilisation of oocytes with spermatozoa isolated from animals with primary testicular damage (PTD). Embryos derived in vivo or in vitro from oocytes fertilised with spermatozoa produced by PTD rats that had undergone surgical treatment for the PTD (group A1), or PTD rats (group A2), or control rats (group B) were cultured and transferred to recipients. At the end of the experimental period, the fertilisation potential of each rat was assessed in vitro (IVF trials). Sperm 8-oxodG/dG ratio (a marker of DNA oxidative status) was significantly larger in group A2 than in groups A1 and B. Blastocysts of the group A2 transferred to recipients demonstrated a significantly larger loss before implantation than transferred blastocysts of groups A1 or B. In addition, the proportion of implanted blastocysts that could not complete the intrauterine development was significantly larger in group A2 than in groups A1 and B. This study reveals a post-fertilisation detrimental effect in animals with PTD on the capacity of oocytes (fertilised either in vitro or in vivo) to develop in vitro and implant after transferring them to recipients probably attributable to sperm DNA oxidative damage.en
heal.journalNameAndrologiaen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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