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https://olympias.lib.uoi.gr/jspui/handle/123456789/22049Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Milionis, H. J. | en |
| dc.contributor.author | Kakafika, A. I. | en |
| dc.contributor.author | Tsouli, S. G. | en |
| dc.contributor.author | Athyros, V. G. | en |
| dc.contributor.author | Bairaktari, E. T. | en |
| dc.contributor.author | Seferiadis, K. I. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.date.accessioned | 2015-11-24T19:20:34Z | - |
| dc.date.available | 2015-11-24T19:20:34Z | - |
| dc.identifier.issn | 1097-6744 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22049 | - |
| dc.rights | Default Licence | - |
| dc.subject | Female | en |
| dc.subject | Heptanoic Acids/*pharmacology/therapeutic use | en |
| dc.subject | Homeostasis/drug effects | en |
| dc.subject | Humans | en |
| dc.subject | Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology/therapeutic use | en |
| dc.subject | Hyperlipidemias/blood/*drug therapy/metabolism | en |
| dc.subject | Hypolipidemic Agents/pharmacology/therapeutic use | en |
| dc.subject | Lipids/blood | en |
| dc.subject | Logistic Models | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Pyrroles/*pharmacology/therapeutic use | en |
| dc.subject | Simvastatin/*pharmacology/therapeutic use | en |
| dc.subject | Uric Acid/*blood/urine | en |
| dc.title | Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1016/j.ahj.2004.04.005 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15459594 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0002870304001930/1-s2.0-S0002870304001930-main.pdf?_tid=1655067b424c589f38d4488b003c0410&acdnat=1333534263_7b77309ea7546fdcffd4abb52b9d2a7b | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2004 | - |
| heal.abstract | BACKGROUND: Epidemiologic studies have shown that serum uric acid is a risk factor of coronary artery disease. In addition to fenofibrate, there is some evidence that atorvastatin may have a hypouricemic action, but the underlying mechanisms remain speculative. METHODS: This randomized trial was conducted to investigate the effects of atorvastatin and simvastatin on uric acid homeostasis in patients treated for primary hyperlipidemia. A total of 180 patients were enrolled; patients were randomly assigned to 40 mg/d of either atorvastatin or simvastatin. Serum lipid and metabolic parameters were measured at baseline and at 6 and 12 weeks of treatment; random urine samples were simultaneously obtained for creatinine, sodium, and uric acid determinations. RESULTS: Baseline serum uric acid levels correlated positively with the body mass index, serum insulin, creatinine, and triglyceride levels and inversely with serum HDL cholesterol levels. Both statins caused a favorable effect on lipids and a significant decrease in fibrinogen and high-sensitivity CRP levels. However, only atorvastatin reduced serum uric acid levels (from 5.6 +/- 1.7 to 4.9 +/- 1.5 mg/dL, P <.0001) by augmenting its urinary fractional excretion (from 10.4% +/- 7.9% to 12.0% +/- 7.4%, P <.01). In a multivariate logistic regression analysis, the reduction of uric acid levels was independently associated with baseline serum uric acid concentration but not to other variables, including lipid parameters (OR, 1.65; 95% CI, 1.14 to 2.40; P =.008). CONCLUSIONS: Atorvastatin (but not simvastatin) significantly lowered serum uric acid levels. This result may be in favor of a preferable choice of atorvastatin for the treatment of hyperlipidemic patients presenting with hyperuricemia. | en |
| heal.journalName | Am Heart J | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Milionis-2004-Effects of statin tr.pdf | 101.76 kB | Adobe PDF | View/Open Request a copy |
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