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dc.contributor.authorKalef-Ezra, J. A.en
dc.contributor.authorPavlidis, N.en
dc.contributor.authorKlouvas, G.en
dc.contributor.authorKarantanas, A.en
dc.contributor.authorHatzikonstantinou, I.en
dc.contributor.authorGlaros, D.en
dc.date.accessioned2015-11-24T19:20:01Z-
dc.date.available2015-11-24T19:20:01Z-
dc.identifier.issn0167-6806-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22004-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntineoplastic Agents, Hormonal/*pharmacologyen
dc.subjectBone Density/*drug effectsen
dc.subjectBreast Neoplasms/*drug therapy/physiopathologyen
dc.subjectChemotherapy, Adjuvanten
dc.subjectCross-Sectional Studiesen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLongitudinal Studiesen
dc.subjectMiddle Ageden
dc.subjectPhosphorus/analysisen
dc.subjectTamoxifen/*pharmacologyen
dc.subjectTime Factorsen
dc.titleElemental composition of bone minerals in women with breast cancer treated with adjuvant tamoxifenen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8750583-
heal.identifier.secondaryhttp://www.springerlink.com/content/l284728811505277/fulltext.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1996-
heal.abstractOestrogen levels play a major role in conditioning the rates of bone changes in women. Tamoxifen is a synthetic oestrogen antagonist commonly used as an adjuvant therapy for breast cancer. The goal of the present study was to study the amount and the elemental composition of bone minerals in the appedicular skeleton of women with breast cancer treated with adjuvant tamoxifen, as well as to investigate the possibility of increased risk for osteoporosis. Forty-two patients, aged 41-65 years, without skeletal metastases were studied. The mean duration of tamoxifen administration on a daily dose of 20 mg was 21 months (range 1-59 months). It was found that neither the amount of phosphorus in hands (HBP) nor forearm bone mineral content (BMC) differ statistically from those of age-matched healthy subjects. This was confirmed by reassessing bone mineral status after 30 months in 17 postmenopausal patients treated with tamoxifen for a mean time of 52 months. In conclusion, our data support that long-term tamoxifen treatment has no adverse or protective effect on the amount and elemental composition of the appedicular skeleton.en
heal.journalNameBreast Cancer Res Treaten
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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