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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21993
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dc.contributor.authorAmmon-Treiber, S.en
dc.contributor.authorGrecksch, G.en
dc.contributor.authorAngelidis, C.en
dc.contributor.authorVezyraki, P.en
dc.contributor.authorHollt, V.en
dc.contributor.authorBecker, A.en
dc.date.accessioned2015-11-24T19:19:52Z-
dc.date.available2015-11-24T19:19:52Z-
dc.identifier.issn1095-9564-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21993-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAvoidance Learning/physiologyen
dc.subjectConditioning, Classical/physiologyen
dc.subjectEmotions/*physiologyen
dc.subjectFear/physiologyen
dc.subjectGene Expression/*geneticsen
dc.subjectHSP70 Heat-Shock Proteins/*geneticsen
dc.subjectHippocampus/anatomy & histology/*physiologyen
dc.subjectLong-Term Potentiation/*geneticsen
dc.subjectMaleen
dc.subjectMaze Learning/*physiologyen
dc.subjectMiceen
dc.subjectMice, Transgenicen
dc.subjectMotivationen
dc.subjectMotor Activity/geneticsen
dc.subjectMotor Skills/*physiologyen
dc.subjectPostural Balance/physiologyen
dc.subjectReaction Time/geneticsen
dc.subjectStereotyped Behavior/*physiologyen
dc.titleEmotional and learning behaviour in mice overexpressing heat shock protein 70en
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.nlm.2008.04.006-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18511309-
heal.identifier.secondaryhttp://ac.els-cdn.com/S107474270800066X/1-s2.0-S107474270800066X-main.pdf?_tid=c5453e74fc2732c560ddb6fd55abebc9&acdnat=1333016601_a0b534b657d70c82876644299b0d79f8-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2008-
heal.abstractThe effects of inducible heat shock protein 70 (HSP70) on emotional and learning behaviour as well as hippocampal long-term potentiation was investigated in transgenic HSP70 overexpressing mice. In active two-way avoidance learning (shuttle box) as well as spatial 8-arm radial maze learning, the HSP70 overexpressing mice showed diminished learning performance. In several tests there was no indication of differences in anxiety behaviour between transgenic mice and wild-type mice. This suggests that impairment in learning behaviour is unrelated to the learning task and motivational aspects of behaviour. To investigate the neurophysiological correlate of learning, long-term potentiation experiments were performed. In transversal hippocampal slices, an enhanced amplitude of the population spike was found in HSP70 overexpressing mice. It was hypothesised that enhanced potentiation in conjunction with potentiation effects due to learning led to learning impairment.en
heal.journalNameNeurobiol Learn Memen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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