Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/21966Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Baltogiannis, G. G. | en |
| dc.contributor.author | Tsalikakis, D. G. | en |
| dc.contributor.author | Mitsi, A. C. | en |
| dc.contributor.author | Hatzistergos, K. E. | en |
| dc.contributor.author | Elaiopoulos, D. | en |
| dc.contributor.author | Fotiadis, D. I. | en |
| dc.contributor.author | Kyriakides, Z. S. | en |
| dc.contributor.author | Kolettis, T. M. | en |
| dc.date.accessioned | 2015-11-24T19:19:31Z | - |
| dc.date.available | 2015-11-24T19:19:31Z | - |
| dc.identifier.issn | 0008-6363 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21966 | - |
| dc.rights | Default Licence | - |
| dc.subject | Action Potentials/drug effects | en |
| dc.subject | Animals | en |
| dc.subject | Arrhythmias, Cardiac/*drug therapy/etiology/physiopathology | en |
| dc.subject | Electrocardiography, Ambulatory | en |
| dc.subject | Female | en |
| dc.subject | Myocardial Infarction/complications/*drug therapy/physiopathology | en |
| dc.subject | Peptides, Cyclic/*therapeutic use | en |
| dc.subject | Random Allocation | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Receptor, Endothelin A/*antagonists & inhibitors | en |
| dc.subject | Tachycardia, Ventricular/drug therapy/physiopathology | en |
| dc.subject | Telemetry/methods | en |
| dc.subject | Ventricular Fibrillation/drug therapy/physiopathology | en |
| dc.title | Endothelin receptor--a blockade decreases ventricular arrhythmias after myocardial infarction in rats | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1016/j.cardiores.2005.04.020 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15907816 | - |
| heal.identifier.secondary | http://cardiovascres.oxfordjournals.org/content/67/4/647.full.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2005 | - |
| heal.abstract | OBJECTIVE: Endothelin-1 (ET-1) production increases during acute myocardial infarction (MI) and may contribute to the genesis of ventricular tachycardia (VT) and ventricular fibrillation (VF). However, the antiarrhythmic effects of ET-1 receptor blockade, examined shortly after MI, have been debated. In the present study, we examined the effects of such treatment on VT/VF during the first 24 h post-MI. METHODS: Thirty-five Wistar rats (223+/-22 g) were randomly allocated to either the ET-1 receptor-A (ETA) antagonist BQ-123 (0.4 mg/kg, BQ-123 group, n=17), or normal saline (control group, n=18) and were subjected to coronary artery ligation. A single-lead electrocardiogram was continuously recorded for 24 h post-MI, using an implanted telemetry system, and episodes of VT/VF were analyzed. Monophasic action potential (MAP) recordings were obtained from the left (LV) and right (RV) ventricular epicardium at baseline, 5 min after treatment and 24 h post-MI. RESULTS: There were 15.94+/-19.35 episodes/h/rat of VT/VF in the control group and 1.66+/-2.22 in the BQ-123 group (p=0.010), resulting in a lower (p=0.030) arrhythmic mortality in treated animals. The mean episode duration was 7.40+/-7.16 s for the control group and 2.30+/-1.37 s for the BQ-123 group (p=0.011). The maximum decrease in VT/VF was observed during the 1st, 5th and 6th hours post-MI. In the control group, LV MAP duration increased 24 h post-MI, displaying an increased beat-to-beat variation, but remained unchanged in the BQ-123 group. CONCLUSION: Acute ETA blockade reduces the incidence of VT/V F during the first 24-h post-MI in the rat, through a decrease in the dispersion of repolarization. | en |
| heal.journalName | Cardiovasc Res | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Baltogiannis-2005-Endothelin receptor-.pdf | 245.54 kB | Adobe PDF | View/Open Request a copy |
This item is licensed under a Creative Commons License
