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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kolettis, T. M. | en |
| dc.contributor.author | Kyriakides, Z. S. | en |
| dc.contributor.author | Zygalaki, E. | en |
| dc.contributor.author | Kyrzopoulos, S. | en |
| dc.contributor.author | Kaklamanis, L. | en |
| dc.contributor.author | Nikolaou, N. | en |
| dc.contributor.author | Lianidou, E. S. | en |
| dc.contributor.author | Kremastinos, D. T. | en |
| dc.date.accessioned | 2015-11-24T19:19:29Z | - |
| dc.date.available | 2015-11-24T19:19:29Z | - |
| dc.identifier.issn | 1383-875X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21964 | - |
| dc.rights | Default Licence | - |
| dc.subject | Aged | en |
| dc.subject | Atrial Fibrillation/*physiopathology | en |
| dc.subject | Biopsy | en |
| dc.subject | Chi-Square Distribution | en |
| dc.subject | Coronary Artery Bypass, Off-Pump | en |
| dc.subject | Endothelins/*metabolism | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Predictive Value of Tests | en |
| dc.subject | RNA, Messenger/metabolism | en |
| dc.subject | ROC Curve | en |
| dc.subject | Reverse Transcriptase Polymerase Chain Reaction | en |
| dc.subject | Sensitivity and Specificity | en |
| dc.subject | Statistics, Nonparametric | en |
| dc.title | Endothelin system and atrial fibrillation post-cardiac surgery | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1007/s10840-008-9206-5 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/18264746 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/ul182235u7680257/fulltext.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2008 | - |
| heal.abstract | OBJECTIVE: We investigated the relation between the endothelin system and atrial fibrillation. BACKGROUND: Endothelin has been implicated in the pathophysiology of atrial fibrillation, but the exact role of A- and B-receptors is unknown. METHODS: We obtained right atrial biopsies from patients in sinus rhythm and preserved left ventricular function, undergoing off-pump coronary artery bypass grafting. The expression of endothelin, A- and B-receptors was measured using real time reverse-transcribed polymerase chain reaction. RESULTS: We studied 52 patients (45 male, mean age 66+/-1 years, mean ejection fraction 52+/-1%). During a 5-day post-operative period, persistent atrial fibrillation occurred in 15 patients (28.8%). Endothelin mRNA expression was comparable in patients who subsequently developed atrial fibrillation and in those maintaining sinus rhythm. However, the former group displayed down-regulation of endothelin A- (by approximately 60%, p=0.0059) and of B-receptors (by approximately 40%, p=0.0084). The decreased endothelin A-receptor expression could predict atrial fibrillation occurrence (Wilks lambda=0.86, F=6.16, p=0.017). CONCLUSION: Decreased endothelin A- and B-receptor expression is associated with atrial fibrillation after bypass surgery. | en |
| heal.journalName | J Interv Card Electrophysiol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kolettis-2008-Endothelin system an.pdf | 137.29 kB | Adobe PDF | View/Open Request a copy |
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