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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Oikonomidis, D. L. | en |
| dc.contributor.author | Tsalikakis, D. G. | en |
| dc.contributor.author | Baltogiannis, G. G. | en |
| dc.contributor.author | Tzallas, A. T. | en |
| dc.contributor.author | Xourgia, X. | en |
| dc.contributor.author | Agelaki, M. G. | en |
| dc.contributor.author | Megalou, A. J. | en |
| dc.contributor.author | Fotopoulos, A. | en |
| dc.contributor.author | Papalois, A. | en |
| dc.contributor.author | Kyriakides, Z. S. | en |
| dc.contributor.author | Kolettis, T. M. | en |
| dc.date.accessioned | 2015-11-24T19:19:28Z | - |
| dc.date.available | 2015-11-24T19:19:28Z | - |
| dc.identifier.issn | 1435-1803 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21963 | - |
| dc.rights | Default Licence | - |
| dc.subject | Action Potentials | en |
| dc.subject | Adrenergic beta-Antagonists/therapeutic use | en |
| dc.subject | Animals | en |
| dc.subject | Catecholamines/blood | en |
| dc.subject | Electrocardiography | en |
| dc.subject | Heart Rate | en |
| dc.subject | Myocardial Infarction/complications/*metabolism/pathology/physiopathology | en |
| dc.subject | Myocardium/pathology | en |
| dc.subject | Rats | en |
| dc.subject | Receptor, Endothelin B/genetics/*metabolism | en |
| dc.subject | Tachycardia, Ventricular/etiology/*metabolism/prevention & control | en |
| dc.subject | Ventricular Dysfunction, Left | en |
| dc.subject | Ventricular Fibrillation/etiology/*metabolism/prevention & control | en |
| dc.title | Endothelin-B receptors and ventricular arrhythmogenesis in the rat model of acute myocardial infarction | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1007/s00395-009-0066-7 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19838761 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/bh864857273m070g/fulltext.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2010 | - |
| heal.abstract | The arrhythmogenic effects of endothelin-1 (ET-1) are mediated via ETA-receptors, but the role of ETB-receptors is unclear. We examined the pathophysiologic role of ETB-receptors on ventricular tachyarrhythmias (VT/VF) during myocardial infarction (MI). MI was induced by coronary ligation in two animal groups, namely in wild-type (n = 63) and in ETB-receptor-deficient (n = 61) rats. Using a telemetry recorder, VT/VF episodes were evaluated during phase I (the 1st hour) and phase II (2-24 h) post-MI, with and without prior beta-blockade. Action potential duration at 90% repolarization (APD90) was measured from monophasic epicardial recordings and indices of sympathetic activation were assessed using fast-Fourier analysis of heart rate variability. Serum epinephrine and norepinephrine were measured with radioimmunoassay. MI size was similar in the two groups. There was a marked temporal variation in VT/VF duration; during phase I, it was higher (p = 0.0087) in ETB-deficient (1,519 +/- 421 s) than in wild-type (190 +/- 34 s) rats, but tended (p = 0.086) to be lower in ETB-deficient (4.2 +/- 2.0 s) than in wild-type (27.7 +/- 8.0 s) rats during phase II. Overall, the severity of VT/VF was greater in ETB-deficient rats, evidenced by higher (p = 0.0058) mortality (72.0% vs. 32.1%). There was a temporal variation in heart rate and in the ratio of low- to high-frequency spectra, being higher (<0.001) during phase I, but lower (p < 0.05) during phase II in ETB-deficient rats. Likewise, 1 h post-MI, serum epinephrine (p = 0.025) and norepinephrine (p < 0.0001) were higher in ETB-deficient (4.20 +/- 0.54, 14.24 +/- 1.39 ng/ml) than in wild-type (2.30 +/- 0.59, 5.26 +/- 0.67 ng/ml) rats, respectively. After beta-blockade, VT/VF episodes and mortality were similar in the two groups. The ETB-receptor decreases sympathetic activation and arrhythmogenesis during the early phase of MI, but these effects diminish during evolving MI. | en |
| heal.journalName | Basic Res Cardiol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Oikonomidis-2010-Endothelin-B recepto.pdf | 357.85 kB | Adobe PDF | View/Open Request a copy |
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