Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21948
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dc.contributor.authorSchweigerer, L.en
dc.contributor.authorScheurich, P.en
dc.contributor.authorFotsis, T.en
dc.date.accessioned2015-11-24T19:19:17Z-
dc.date.available2015-11-24T19:19:17Z-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21948-
dc.rightsDefault Licence-
dc.subjectCell Division/drug effectsen
dc.subjectGene Expression Regulation, Neoplastic/drug effectsen
dc.subjectHumansen
dc.subjectNeuroblastoma/*metabolism/pathologyen
dc.subject*Oncogenesen
dc.subjectProto-Oncogene Proteins/*biosynthesisen
dc.subjectProto-Oncogene Proteins c-mycen
dc.subject*Proto-Oncogenesen
dc.subjectRecombinant Proteins/pharmacologyen
dc.subjectTransfectionen
dc.subjectTumor Cells, Cultured/cytology/drug effects/metabolismen
dc.subjectTumor Necrosis Factor-alpha/*pharmacologyen
dc.titleEnhanced MYCN oncogene expression in human neuroblastoma cells results in increased susceptibility to growth inhibition by TNF alphaen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/2202299-
heal.identifier.secondaryhttp://ac.els-cdn.com/0006291X9090535U/1-s2.0-0006291X9090535U-main.pdf?_tid=c8fb8b9079c25a6346b144997e01d8c8&acdnat=1332753537_8772120de5664b39abc3a92612884007-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1990-
heal.abstractHuman neuroblastoma cells with normal expression of the endogenous MYCN oncogene were transfected with a vector containing an exogenous MYCN gene. The transfected cells expressed the exogenous MYCN at high levels and had acquired a phenotype resembling that of cells from advanced human neuroblastomas. Proliferation of the MYCN-transfected, but not of the untransfected, neuroblastoma cells was inhibited by low concentrations of recombinant human tumor necrosis factor alpha (TNF alpha). Our results suggest that TNF alpha could be useful for the treatment of advanced human neuroblastomas, in which high MYCN expression seems to be a causative factor.en
heal.journalNameBiochem Biophys Res Communen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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