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https://olympias.lib.uoi.gr/jspui/handle/123456789/21946Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Pelidou, S. H. | en |
| dc.contributor.author | Zou, L. P. | en |
| dc.contributor.author | Deretzi, G. | en |
| dc.contributor.author | Oniding, C. | en |
| dc.contributor.author | Mix, E. | en |
| dc.contributor.author | Zhu, J. | en |
| dc.date.accessioned | 2015-11-24T19:19:16Z | - |
| dc.date.available | 2015-11-24T19:19:16Z | - |
| dc.identifier.issn | 0014-4886 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21946 | - |
| dc.rights | Default Licence | - |
| dc.subject | Acute Disease | en |
| dc.subject | Administration, Intranasal | en |
| dc.subject | Animals | en |
| dc.subject | Cells, Cultured | en |
| dc.subject | Chronic Disease | en |
| dc.subject | Disease Progression | en |
| dc.subject | Dose-Response Relationship, Drug | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Interleukin-17/administration & dosage/*immunology | en |
| dc.subject | Leukocytes, Mononuclear/cytology/drug effects | en |
| dc.subject | Lymphocyte Activation/drug effects/immunology | en |
| dc.subject | Male | en |
| dc.subject | Mice | en |
| dc.subject | Myelin P2 Protein/immunology | en |
| dc.subject | Neuritis, Autoimmune, Experimental/*immunology/pathology | en |
| dc.subject | Peptide Fragments/immunology | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Inbred Lew | en |
| dc.subject | Recombinant Proteins/administration & dosage/immunology/therapeutic use | en |
| dc.subject | Sciatic Nerve/drug effects/pathology | en |
| dc.subject | Tumor Necrosis Factor-alpha/metabolism | en |
| dc.title | Enhancement of acute phase and inhibition of chronic phase of experimental autoimmune neuritis in Lewis rats by intranasal administration of recombinant mouse interleukin 17: potential immunoregulatory role | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1006/exnr.2000.7357 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10785455 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0014488600973576/1-s2.0-S0014488600973576-main.pdf?_tid=bcff35d1260c14239710b3ce2f6f4eec&acdnat=1332844618_80dd581d1d066ba347bdc6937731c840 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2000 | - |
| heal.abstract | Experimental autoimmune neuritis (EAN) is a CD4(+) T-cell-mediated demyelinating disease of the peripheral nervous system (PNS). We examined the effect of recombinant mouse interleukin 17 (rmIL-17) on chronic EAN induced in Lewis rats by inoculation of P2 57-81 peptide in Freund's complete adjuvant. Animals were treated nasally for 6 days with either 0.1 or 0.9 microg/rat/day rmIL-17 from the onset of neurological signs, i.e., days 9 to 14 postimmunization (p.i.). Prolonged follow-up demonstrated a chronic course in control and rmIL-17-treated rats. Treated rats had more severe disease initially (days 18-36 p.i.) with a stronger enhancing effect observed with the higher rmIL-17 dose. At day 19 rmIL-17-treated rats showed increased infiltration of inflammatory cells into the sciatic nerve, more severe demyelination, augmented proliferation of regional lymph node cells, and increased serum levels of tumor necrosis factor-alpha. After the initial phase of disease enhancement the IL-17-treated EAN rats improved gradually and ultimately recovered completely, whereas the control EAN rats remained affected until the end of the observation (day 120 p.i.). The lower dose of rmIL-17 induced an earlier recovery from clinical deficits than the higher one. The results indicate that IL-17 plays an immunoregulatory role in chronic EAN which could have implications for immunomodulatory treatments of chronic autoimmune disease of the PNS. | en |
| heal.journalName | Exp Neurol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Pelidou-2000-Enhancement of acute.pdf | 359.03 kB | Adobe PDF | View/Open Request a copy |
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