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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21892
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dc.contributor.authorKanavaros, P.en
dc.contributor.authorBriere, J.en
dc.contributor.authorLescs, M. C.en
dc.contributor.authorGaulard, P.en
dc.date.accessioned2015-11-24T19:18:43Z-
dc.date.available2015-11-24T19:18:43Z-
dc.identifier.issn0022-3417-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21892-
dc.rightsDefault Licence-
dc.subjectAntigens, Differentiation, T-Lymphocyte/immunologyen
dc.subjectHerpesvirus 4, Human/genetics/immunology/*isolation & purificationen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectImmunophenotypingen
dc.subjectIn Situ Hybridizationen
dc.subjectKiller Cells, Natural/immunologyen
dc.subjectLymphoma, Non-Hodgkin/immunology/*virologyen
dc.subjectParanasal Sinus Neoplasms/immunology/*virologyen
dc.subjectRNA, Messenger/analysisen
dc.subjectRNA, Viral/analysisen
dc.subjectT-Lymphocytes/immunologyen
dc.subjectTonsillar Neoplasms/immunology/*virologyen
dc.subjectViral Matrix Proteins/analysisen
dc.titleEpstein-Barr virus in non-Hodgkin's lymphomas of the upper respiratory tract: association with sinonasal localization and expression of NK and/or T-cell antigens by tumour cellsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1002/(SICI)1096-9896(199603)178:3<297::AID-PATH469>3.0.CO;2-E-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8778335-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/(SICI)1096-9896(199603)178:3<297::AID-PATH469>3.0.CO;2-E/asset/469_ftp.pdf?v=1&t=h0exc9l1&s=b7a2d83d218cbe7abf184c76942756463e82add1-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1996-
heal.abstractFifty-five cases of non-Hodgkin's lymphoma (NHL) of the upper respiratory tract, comprising 27 sinonasal (SN) and 28 Waldeyer's ring (WR) NHL, were investigated for expression of Epstein-Barr virus (EBV)-encoded EBER transcripts and latent membrane protein-1 (LMP-1) by RNA in-situ hybridization (RISH) and immunohistochemistry, respectively. Thirty-two cases were B-cell tumours (10 SNHLs and 22 WRNHLs) and 23 cases expressed natural killer (NK) and/or T-cell antigens (17 SNHLs and 6 WRNHLs). EBER transcripts were detected in tumour cells in 19 lymphomas expressing NK and/or T-cell antigens (16/17 SHNHLs and 3/6 WRNHLs) but in only 2/32 B-NHLs (1/10 SNHLs and 1/22 WRNHLs). LMP-1 expression was found in tumour cells in the 19 EBER-positive tumours expressing NK and/or T-cell antigens but in none of the B-cell lymphomas. All the LMP-1-positive lymphomas expressed the CD30 molecule in tumour cells. These results indicate that in lymphomas of the upper respiratory tract, EBV is strongly associated with sinonasal localization and expression of NK and/or T-cell antigens by tumour cells. EBV can also be detected in some cases of WRNHLs expressing NK and/or T-cell antigens, whereas it is rarely found in B-cell SNHLs and WRNHLs. Furthermore, the detection of the LMP-1 protein in tumour cells in most SNHLs and some WRNHLs expressing NK and/or T-cell antigens, in view of the LMP-1 transforming potential, suggests that EBV may play a role in the pathogenesis of these lymphomas.en
heal.journalNameJ Patholen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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