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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21827
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dc.contributor.authorValentini, G.en
dc.contributor.authorDella Rossa, A.en
dc.contributor.authorBombardieri, S.en
dc.contributor.authorBencivelli, W.en
dc.contributor.authorSilman, A. J.en
dc.contributor.authorD'Angelo, S.en
dc.contributor.authorCerinic, M. M.en
dc.contributor.authorBelch, J. F.en
dc.contributor.authorBlack, C. M.en
dc.contributor.authorBruhlman, P.en
dc.contributor.authorCzirjak, L.en
dc.contributor.authorDe Luca, A.en
dc.contributor.authorDrosos, A. A.en
dc.contributor.authorFerri, C.en
dc.contributor.authorGabrielli, A.en
dc.contributor.authorGiacomelli, R.en
dc.contributor.authorHayem, G.en
dc.contributor.authorInanc, M.en
dc.contributor.authorMcHugh, N. J.en
dc.contributor.authorNielsen, H.en
dc.contributor.authorRosada, M.en
dc.contributor.authorScorza, R.en
dc.contributor.authorStork, J.en
dc.contributor.authorSysa, A.en
dc.contributor.authorvan den Hoogen, F. H.en
dc.contributor.authorVlachoyiannopoulos, P. J.en
dc.date.accessioned2015-11-24T19:17:55Z-
dc.date.available2015-11-24T19:17:55Z-
dc.identifier.issn0003-4967-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21827-
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAnalysis of Varianceen
dc.subjectChilden
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLinear Modelsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectProspective Studiesen
dc.subjectROC Curveen
dc.subjectReproducibility of Resultsen
dc.subjectScleroderma, Systemic/complications/*diagnosisen
dc.subject*Severity of Illness Indexen
dc.subjectSingle-Blind Methoden
dc.titleEuropean multicentre study to define disease activity criteria for systemic sclerosis. II. Identification of disease activity variables and development of preliminary activity indexesen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11350848-
heal.identifier.secondaryhttp://ard.bmj.com/content/60/6/592.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2001-
heal.abstractOBJECTIVE: To develop criteria for disease activity in systemic sclerosis (SSc) that are valid, reliable, and easy to use. METHODS: Investigators from 19 European centres completed a standardised clinical chart for a consecutive number of patients with SSc. Three protocol management members blindly evaluated each chart and assigned a disease activity score on a semiquantitative scale of 0-10. Two of them, in addition, gave a blinded, qualitative evaluation of disease activity ("inactive to moderately active" or "active to very active" disease). Both these evaluations were found to be reliable. A final disease activity score and qualitative evaluation of disease activity were arrived at by consensus for each patient; the former represented the gold standard for subsequent analyses. The correlations between individual items in the chart and this gold standard were then analysed. RESULTS: A total of 290 patients with SSc (117 with diffuse SSc (dSSc) and 173 with limited SSc (lSSc)) were enrolled in the study. The items (including Delta-factors-that is, worsening according to the patient report) that were found to correlate with the gold standard on multiple regression were used to construct three separate 10-point indices of disease activity: (a) Delta-cardiopulmonary (4.0), Delta-skin (3.0), Delta-vascular (2.0), and Delta-articular/muscular (1.0) for patients with dSSc; (b) Delta-skin (2.5), erythrocyte sedimentation rate (ESR) >30 mm/1st h (2.5), Delta-cardiopulmonary (1.5), Delta-vascular (1.0), arthritis (1.0), hypocomplementaemia (1.0), and scleredema (0.5) for lSSc; (c) Delta-cardiopulmonary (2.0), Delta-skin (2.0), ESR >30 mm/1st h (1.5), total skin score >20 (1.0), hypocomplementaemia (1.0), scleredema (0.5), digital necrosis (0.5), Delta-vascular (0.5), arthritis (0.5), TLCO <80% (0.5) for all patients with SSc. The three indexes were validated by the jackknife technique. Finally, receiver operating characteristic curves were constructed in order to define the value of the index with the best discriminant capacity for "active to very active" patients. CONCLUSIONS: Three feasible, reliable, and valid preliminary indices to define disease activity in SSc were constructed.en
heal.journalNameAnn Rheum Disen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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