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https://olympias.lib.uoi.gr/jspui/handle/123456789/21822Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Alexiou, G. A. | en |
| dc.contributor.author | Fotopoulos, A. D. | en |
| dc.contributor.author | Papadopoulos, A. | en |
| dc.contributor.author | Kyritsis, A. P. | en |
| dc.contributor.author | Polyzoidis, K. S. | en |
| dc.contributor.author | Tsiouris, S. | en |
| dc.date.accessioned | 2015-11-24T19:17:52Z | - |
| dc.date.available | 2015-11-24T19:17:52Z | - |
| dc.identifier.issn | 0914-7187 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21822 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Brain/pathology/radionuclide imaging | en |
| dc.subject | Brain Neoplasms/*diagnosis/*pathology/radionuclide imaging | en |
| dc.subject | Cell Line, Tumor | en |
| dc.subject | Female | en |
| dc.subject | Glioma/diagnosis/*radionuclide imaging | en |
| dc.subject | Humans | en |
| dc.subject | Magnetic Resonance Imaging/methods | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Organophosphorus Compounds/*pharmacology | en |
| dc.subject | Organotechnetium Compounds/*pharmacology | en |
| dc.subject | Pilot Projects | en |
| dc.subject | Radiopharmaceuticals/*pharmacology | en |
| dc.subject | *Recurrence | en |
| dc.subject | Tomography, Emission-Computed, Single-Photon/*methods | en |
| dc.subject | Tomography, X-Ray Computed/methods | en |
| dc.title | Evaluation of brain tumor recurrence by (99m)Tc-tetrofosmin SPECT: a prospective pilot study | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1007/s12149-007-0027-x | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17634847 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/qm70606643xq04q1/fulltext.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2007 | - |
| heal.abstract | OBJECTIVE: The differentiation between brain tumor recurrence and post-irradiation injury remains an imaging challenge. Computed tomography (CT) and magnetic resonance imaging (MRI) cannot always distinguish between the two. Although glioma cell line studies substantiated a plausible imaging superiority of (99m)Tc-tetrofosmin ((99m)Tc-TF) over other radiopharmaceuticals, little has been reported on its in vivo imaging properties. We assessed (99m)Tc-TF single-photon emission CT (SPECT) in cases where morphologic brain imaging was inconclusive between recurrence and radionecrosis. METHODS: A total of 11 patients (7 men, 4 women) were evaluated. The initial diagnosis was glioblastoma multiforme (4), anaplastic astrocytoma (1), anaplastic oligodendroglioma (3), grade-II astrocytoma (2), and low-grade oligodendroglioma (1). All patients had been operated on and then received adjuvant external-beam radiotherapy. After a mean follow-up period of 25 months, there was clinical suspicion of recurrence, for which (99m)Tc-TF SPECT was performed. RESULTS: In 8/11 cases, an abnormally increased tracer uptake appeared in the region that CT and/or MRI indicated as suspicious; in half of these cases, recurrence was confirmed histologically after surgery and in the other four by growth of the lesion over a 6-month follow-up period, and clinical deterioration. The remaining 3/11 patients had faint tracer uptake in the suspicious region, compatible with radiation injury; these lesions remained morphologically unaltered in a mean 12-month follow-up period, with no clinical deterioration in the patient's condition, a course strongly favoring the diagnosis of radiation injury. CONCLUSIONS: Metabolic brain imaging by (99m)Tc-TF could offer useful information in the workup of treated brain tumors, where radiomorphologic findings between recurrence and radionecrosis are inconclusive. | en |
| heal.journalName | Ann Nucl Med | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Alexiou-2007-Evaluation of brain.pdf | 254.61 kB | Adobe PDF | View/Open Request a copy |
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