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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bairaktari, E. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.contributor.author | Tzallas, C. | en |
| dc.contributor.author | Karabina, S. A. | en |
| dc.contributor.author | Tselepis, A. D. | en |
| dc.contributor.author | Siamopoulos, K. C. | en |
| dc.contributor.author | Tsolas, O. | en |
| dc.date.accessioned | 2015-11-24T19:17:48Z | - |
| dc.date.available | 2015-11-24T19:17:48Z | - |
| dc.identifier.issn | 0009-9120 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21813 | - |
| dc.rights | Default Licence | - |
| dc.subject | Apolipoproteins B/*blood | en |
| dc.subject | Bias (Epidemiology) | en |
| dc.subject | Cholesterol/blood | en |
| dc.subject | Cholesterol, HDL/*blood | en |
| dc.subject | Cholesterol, LDL/*blood | en |
| dc.subject | Humans | en |
| dc.subject | Linear Models | en |
| dc.subject | Predictive Value of Tests | en |
| dc.subject | Reagent Kits, Diagnostic | en |
| dc.subject | Renal Dialysis | en |
| dc.subject | Renal Insufficiency/*blood | en |
| dc.subject | Reproducibility of Results | en |
| dc.subject | Sensitivity and Specificity | en |
| dc.subject | Triglycerides/blood | en |
| dc.title | Evaluation of five methods for determining low-density lipoprotein cholesterol (LDL-C) in hemodialysis patients(1) | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11849617 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0009912001002740/1-s2.0-S0009912001002740-main.pdf?_tid=49eda556a5bea307d511ae394ac3e7c5&acdnat=1333528454_92d7a043792f4f84bd89614927a73ecd | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2001 | - |
| heal.abstract | OBJECTIVES: Current recommendations for the management of dyslipidemia are largely based on the concentration of LDL-C. Most clinical laboratories estimate the concentration of LDL-C by the recommended routine method, the equation of Friedewald, in specimens from fasting subjects and with TG concentrations < 4.52 mmol/L. Because of the limitations of the Friedewald calculation, direct methods for an accurate quantification of LDL-C are needed. DESIGN AND METHODS: In the present study we evaluated the accuracy of the following 5 different procedures for LDL-C in 98 patients on hemodialysis: the Friedewald equation, where LDL-C is calculated from HDL-C, measured either by the precipitation procedure with dextran sulfate-Mg(2+) (Method 1), or by a direct HDL-C assay (Method 2), the Direct LDL assay (Method 3), the homogeneous N-geneous LDL assay (Method 4) and the calculated LDL-C values deriving from the ApoB based equation: 0.41TC - 0.32TG + 1.70ApoB - 0.27, (Clin Chem 1997;43:808-815) (Method 5). RESULTS: All five LDL-C methods were found to be in good agreement with ultracentrifugation/dextran sulfate-Mg(2+) precipitation with the coefficients of correlation of the assays to ranging between 0.93-0.95. However, significant differences in the mean values and biases vs. the reference method were observed. The Friedewald equation and the Direct assay were less affected by high LDL-C levels, and they presented higher sensitivity and higher negative predictive value. The N-geneous assay and the ApoB derived calculation were less affected by high triglyceride levels, and they presented higher specificity and higher positive predictive value. At the diagnostic LDL-C level of 3.37 mmol/L, both Friedewald calculations correctly classified 82/92 patients; Direct assay 86/98; N-geneous assay 88/98; and ApoB derived calculation 88/98. At the diagnostic LDL-C level of 2.98 mmol/L, Friedewald calculations (Method 1 and Method 2) correctly classified 82/92 and 81/92 patients, respectively; Direct assay (LDL-3) 87/98; N-geneous assay (LDL-4) 91/98; and ApoB derived calculation (LDL-5) 91/98. CONCLUSIONS: Among hemodialysis patients, who commonly present "average" LDL-C concentrations and high TG levels, the N-geneous assay and the apoB derived calculation seem to yield more acceptable results for the estimation of LDL-C. | en |
| heal.journalName | Clin Biochem | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Bairaktari-2001-Evaluation of five m.pdf | 273.8 kB | Adobe PDF | View/Open Request a copy |
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