1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21729
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTsiolis, I.en
dc.contributor.authorPapalois, A.en
dc.contributor.authorLoukopoulos, I.en
dc.contributor.authorGravvanis, A.en
dc.contributor.authorLykoudis, E.en
dc.contributor.authorTheodossopoulou, E.en
dc.contributor.authorChairakakis, A.en
dc.contributor.authorDimitroulopoulos, D.en
dc.contributor.authorSfiniadakis, I.en
dc.contributor.authorVassiliou, I.en
dc.contributor.authorFelekouras, E.en
dc.contributor.authorDedeilias, P.en
dc.contributor.authorKontogiorgi, M.en
dc.contributor.authorPapadimitriou, L.en
dc.contributor.authorPapadimitriou, I.en
dc.date.accessioned2015-11-24T19:16:58Z-
dc.date.available2015-11-24T19:16:58Z-
dc.identifier.issn0041-1345-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21729-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAntibodies, Monoclonal/*therapeutic useen
dc.subjectAntibodies, Monoclonal, Humanizeden
dc.subjectGraft Survivalen
dc.subjectHepatocytes/*cytology/*transplantationen
dc.subjectImmunoglobulin G/*therapeutic useen
dc.subjectImmunosuppressive Agents/*therapeutic useen
dc.subjectLiver Failure, Acute/*surgeryen
dc.subjectMaleen
dc.subjectModels, Animalen
dc.subjectRatsen
dc.subjectRats, Inbred Lewen
dc.subjectRats, Wistaren
dc.subjectReceptors, Interleukin-2/immunologyen
dc.subjectSpleenen
dc.subjectTransplantation, Homologous/*immunologyen
dc.titleExperimental isolation and transplantation of hepatocytes with the use of antibody against interleukin-2 receptor (daclizumab) as immunosuppressive agenten
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1016/j.transproceed.2005.02.097-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15919507-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0041134505002137/1-s2.0-S0041134505002137-main.pdf?_tid=6c7f5e0f151836aebe43c26e30efa7b9&acdnat=1333466359_a0997b78a318651a2cc299834eb56de3-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2005-
heal.abstractINTRODUCTION: Daclizumab (Dmab) is a genetically engineered humanized IgG1 monoclonal antibody that binds to the alpha chain of the interleukin-2 receptor (Tac, CD25, p55) expressed on activated human T lymphocytes. Dmab has been used in a clinical protocol of islet transplantation with satisfactory results. The aim of the present study was to evaluate the use of an antibody against the interleukin-2 receptor (Dmab) as an immunosuppressive agent in an experimental model of hepatocyte allotransplantation (allo-Tx) in rats with fulminant hepatic failure (FHF). MATERIALS AND METHODS: Six Wistar rats were used as donors and 48 Lewis rats as recipients: four groups of 12 animals each with induction of FHF and 24 hour later hepatocyte Tx--group A: no treatment; group B: cyclosporin (20 mg/kg days 0 to 5 and 10 mg/kg days 6 to 15); group C: Dmab (0.05 mg day of Tx and 0.05 mg day 7); and group D: Dmab and cyclosporine. Hepatocytes were transplanted intrasplenically. Animals were followed for 15 days. RESULTS: Statistical analysis showed better survival among groups C (83%, MST = 13) and D (92%, MST = 14.25) compared to groups A (max 72, MST = 1.5) or B (50%, MST = 9). Survival in group D was better but not significantly than group C. Biochemical evaluation and histology confirmed satisfactory function and engraftment, respectively. CONCLUSION: This experimental model showed the safe, effective use of Dmab.en
heal.journalNameTransplant Procen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Show simple item record
Files in This Item:
File Description SizeFormat 
Tsiolis-2005-Experimental isolati.pdf50.56 kBAdobe PDFView/Open    Request a copy
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons