1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21712
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAnagnostopoulos, G. K.en
dc.contributor.authorStefanou, D.en
dc.contributor.authorArkoumani, E.en
dc.contributor.authorChalkley, L.en
dc.contributor.authorKaragiannis, J.en
dc.contributor.authorParaskeva, K.en
dc.contributor.authorMathou, N.en
dc.contributor.authorDellaporta, E.en
dc.contributor.authorTsianos, E.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:16:50Z-
dc.date.available2015-11-24T19:16:50Z-
dc.identifier.issn0001-5644-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21712-
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/*pathology/secondaryen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAntibodies, Monoclonal/diagnostic useen
dc.subjectCarcinoma/pathology/secondaryen
dc.subjectCell Differentiation/geneticsen
dc.subjectColoring Agents/diagnostic useen
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectGastric Mucosa/pathologyen
dc.subjectGene Expression Regulation, Neoplastic/geneticsen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectLymph Nodes/pathologyen
dc.subjectLymphatic Metastasis/pathologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Stagingen
dc.subjectPrognosisen
dc.subjectStomach Neoplasms/*pathologyen
dc.subjectSurvival Rateen
dc.subjectbcl-2-Associated X Protein/*analysisen
dc.titleExpression of Bax protein in gastric carcinomas. A clinicopathological and immunohistochemical studyen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18074738-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2007-
heal.abstractBACKGROUND AND STUDY AIMS: Reduced Bax protein expression has been shown to be a negative prognostic factor in patients with breast, ovarian, colorectal, esophageal and pancreatic cancer. Our aim was to immunohistochemically study Bax protein expression in gastric carcinomas and correlate its expression with clinicopathological parameters and prognosis. PATIENTS AND METHODS: Immunohistochemistry was performed, using a monoclonal antibody against bax, in paraffin-embedded tumor specimens from 47 cases of gastric cancer. RESULTS: Positive staining for the Bax protein was found in 20/47 (42.4%) adenocarcinomas examined. Negative Bax protein expression in tumour cells was correlated with lymph node metastasis (P < 0.05), and degree of differentiation (p < 0.05). Univariate analysis showed that the variables with a significant negative impact on survival were: high TNM tumour stage, depth of penetration in the gastric wall, lymph node involvement, and Bax protein expression. Multivariate analysis showed that the only variable with an impact on survival was Bax protein expression (p < 0.05, Relative Risk: 3.34). Kaplan-Meier curves showed that the 5-year survival was 36.8% in cases with positive compared with 16% in cases with negative Bax protein expression (p = 0.0427). CONCLUSION: Negative Bax expression in gastric cancer is associated with de-differentiation, lymph node metastases, and poor clinical prognosis. Bax protein expression might play an important role in the development and phenotypic differentiation of gastric carcinomas and tumor progression.en
heal.journalNameActa Gastroenterol Belgen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Show simple item record
Files in This Item:
There are no files associated with this item.
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons