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  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21690
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dc.contributor.authorPanelos, J.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorPaglierani, M.en
dc.contributor.authorZioga, A.en
dc.contributor.authorMaio, V.en
dc.contributor.authorSanti, R.en
dc.contributor.authorPimpinelli, N.en
dc.contributor.authorDe Giorgi, V.en
dc.contributor.authorSantucci, M.en
dc.contributor.authorMassi, D.en
dc.date.accessioned2015-11-24T19:16:38Z-
dc.date.available2015-11-24T19:16:38Z-
dc.identifier.issn1530-0285-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21690-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCadherins/*metabolismen
dc.subjectCarcinoid Tumor/metabolism/pathologyen
dc.subjectCarcinoma, Merkel Cell/*metabolism/mortality/secondaryen
dc.subjectCell Adhesionen
dc.subjectCell Membrane/metabolism/pathologyen
dc.subjectCytoplasm/metabolism/pathologyen
dc.subjectDown-Regulationen
dc.subjectFemaleen
dc.subjectFluorescent Antibody Technique, Indirecten
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectReceptor, Notch1/*metabolismen
dc.subjectSkin Neoplasms/*metabolism/mortality/pathologyen
dc.subjectSurvival Rateen
dc.subjectTumor Markers, Biological/metabolismen
dc.subjectbeta Catenin/*metabolismen
dc.titleExpression of Notch-1 and alteration of the E-cadherin/beta-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (Merkel cell carcinoma)en
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1038/modpathol.2009.55-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19396152-
heal.identifier.secondaryhttp://www.nature.com/modpathol/journal/v22/n7/pdf/modpathol200955a.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2009-
heal.abstractIncreasing evidence indicates that Notch signaling contributes to physiological processes, including development and differentiation, as well as tumorigenesis, either as a tumor promoter or suppressor, depending on cellular context, expression levels and cross talk with other signaling systems. Recent studies reported absent or minimal Notch-1 expression in neuroendocrine tumors of the lung and gastrointestinal tract, suggesting a tumor-suppressor function of Notch-1. Merkel cell carcinoma is a rare and highly aggressive primary cutaneous neuroendocrine carcinoma. Because no information is available on Notch-1 expression in this tumor, we have investigated a series of 31 Merkel cell carcinoma for Notch-1 immunoreactivity. Immunoreactivities for E-cadherin and beta-catenin were also analyzed. All but 1 Merkel cell carcinoma (30 of 31) retained cytoplasmic and membrane Notch-1 expression in more than 50% of cells. beta-Catenin displayed a prevalent membrane-associated staining in 30 of 31 cases, and 22 cases showed more than 50% of immunoreactive cells whereas nuclear beta-catenin was seen only in 2 of 31 cases. E-cadherin membranous expression was remarkably low, as only 1 of 26 cases was found positive in more than 50% of cells. In contrast with neuroendocrine tumors in other tissues, evident Notch-1 expression was found in Merkel cell carcinoma. This finding does not support a tumor-suppressor function of Notch-1 in Merkel cell carcinoma. Downregulation of E-cadherin and diffuse membranous beta-catenin expression suggest a dysregulation of the E-cadherin/beta-catenin complex in Merkel cell carcinoma. This may contribute to local invasion and distant metastasis.en
heal.journalNameMod Patholen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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