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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21681
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dc.contributor.authorGaulard, P.en
dc.contributor.authorBourquelot, P.en
dc.contributor.authorKanavaros, P.en
dc.contributor.authorHaioun, C.en
dc.contributor.authorLe Couedic, J. P.en
dc.contributor.authorDivine, M.en
dc.contributor.authorGoossens, M.en
dc.contributor.authorZafrani, E. S.en
dc.contributor.authorFarcet, J. P.en
dc.contributor.authorReyes, F.en
dc.date.accessioned2015-11-24T19:16:34Z-
dc.date.available2015-11-24T19:16:34Z-
dc.identifier.issn0002-9440-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21681-
dc.rightsDefault Licence-
dc.subjectAntibodies, Monoclonal/diagnostic useen
dc.subjectAntigens, CD3en
dc.subjectAntigens, Differentiation, T-Lymphocyte/analysisen
dc.subjectGene Expressionen
dc.subjectGene Rearrangement, alpha-Chain T-Cell Antigen Receptoren
dc.subjectGene Rearrangement, beta-Chain T-Cell Antigen Receptoren
dc.subjectGene Rearrangement, gamma-Chain T-Cell Antigen Receptoren
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectLymphoma/diagnosis/*immunologyen
dc.subjectPhenotypeen
dc.subjectReceptors, Antigen, T-Cell/analysis/genetics/*immunologyen
dc.subjectStaining and Labelingen
dc.subjectT-Lymphocytes/immunologyen
dc.titleExpression of the alpha/beta and gamma/delta T-cell receptors in 57 cases of peripheral T-cell lymphomas. Identification of a subset of gamma/delta T-cell lymphomasen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/1698028-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1990-
heal.abstractFifty-seven cases of peripheral T-cell lymphoma were studied for cell expression of the T-cell receptor (TCR) chains, using monoclonal antibodies specific for the beta chain (beta F1) of the alpha/beta TCR, and for the delta chain (anti-TCR delta-1) of the gamma/delta TCR. Three different patterns were demonstrated: in 39 cases (69%), the phenotype (CD3+beta F1+TCR delta-1-) was that of most normal T cells. A second pattern was found on six cases (10%), which were of CD3+beta F1-TCR delta-1+ phenotype, and in which DNA analysis showed a clonal rearrangement of the delta locus in the five cases studied. It is suggested that these cases are the neoplastic counterpart of the small subpopulation of normal T cells that express gamma delta receptor. It is of considerable interest that these gamma delta lymphomas had unusual clinicopathologic presentations, as one case corresponded to a lethal midline granuloma and the five others to hepatosplenic lymphomas with a sinusal/sinusoidal infiltration in spleen, marrow, and liver. The fact that the distribution of the neoplastic gamma delta cells in the splenic red pulp resembles that of normal gamma delta cells reinforces the concept of a preferential homing of gamma delta T cells to this tissue. A third pattern (CD3 +/- beta F1-TCR delta-1-) was seen in 12 cases (21%), in which, by contrast to normal post-thymic T cells, no evidence of either alpha beta or gamma delta T cell receptor was found.en
heal.journalNameAm J Patholen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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