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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Mitselou, A. | en |
| dc.contributor.author | Ioachim, E. | en |
| dc.contributor.author | Zagorianakou, N. | en |
| dc.contributor.author | Kitsiou, E. | en |
| dc.contributor.author | Vougiouklakis, T. | en |
| dc.contributor.author | Agnantis, N. J. | en |
| dc.date.accessioned | 2015-11-24T19:16:33Z | - |
| dc.date.available | 2015-11-24T19:16:33Z | - |
| dc.identifier.issn | 0392-2936 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21679 | - |
| dc.rights | Default Licence | - |
| dc.subject | Case-Control Studies | en |
| dc.subject | Cyclin D1/*metabolism | en |
| dc.subject | Cyclin E/*metabolism | en |
| dc.subject | Endometrial Neoplasms/*metabolism/pathology | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Ki-67 Antigen/metabolism | en |
| dc.subject | Neoplasm Staging | en |
| dc.subject | Proliferating Cell Nuclear Antigen/metabolism | en |
| dc.subject | Tumor Suppressor Protein p53/metabolism | en |
| dc.title | Expression of the cell-cycle regulatory proteins (cyclins D1 and E) in endometrial carcinomas: correlations with hormone receptor status, proliferating indices, tumor suppressor gene products (p53, pRb), and clinicopathological parameters | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15597850 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2004 | - |
| heal.abstract | PURPOSE OF INVESTIGATION: This study aimed to investigate the immunohistochemical expression of cyclins D1 and E in normal, hyperplastic and neoplastic endometrium, and their correlation with proliferative activity and clinicopathological features. METHODS: We carried out immunohistochemical techniques on archived material of formalin-fixed paraffin-embedded tissues using the antibodies against the cyclins D1 and E, PR-ER, p53, Ki67 (MIB1) and pRb with the streptavidin-biotin-peroxidase method in a total of 20 cases of normal endometrium, 32 cases of hyperplastic endometrium and 66 cases of endometrial carcinomas. RESULTS: Cyclin D1 and E immunoreactivity was observed in the nuclei of tumour cells in 18.2% and 39.1%, respectively, of the cases of endometrial carcinomas. Cyclin D1 labelling index was not significantly correlated with any of the clinicopathologic parameters examined. However, there was a significant correlation between the cyclin E labelling index and histological grade of carcinoma (p = 0.00096), which increased significantly with histological grades of malignancy. We also detected a significant correlation between cyclin E and PCNA (p < 0.0001) as well as with the tumor suppressor genes p53 and pRb (p = 0.052 and 0.0002, respectively) in endometrioid endometrial carcinoma. CONCLUSION: Our results indicate that cyclin E overexpression may be involved in the development and/or proliferation and differentiation of human endometrioid endometrial carcinoma. Immunoexpression of cyclin D1 does not appear to be associated with cell-cycle progression in the benign or malignant endometrium. | en |
| heal.journalName | Eur J Gynaecol Oncol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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