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https://olympias.lib.uoi.gr/jspui/handle/123456789/21658Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kalef-Ezra, J. | en |
| dc.contributor.author | Michalis, L. K. | en |
| dc.contributor.author | Malamou-Mitsi, V. | en |
| dc.contributor.author | Tsekeris, P. | en |
| dc.contributor.author | Katsouras, C. | en |
| dc.contributor.author | Boziari, A. | en |
| dc.contributor.author | Toumpoulis, I. | en |
| dc.contributor.author | Bozios, G. | en |
| dc.contributor.author | Charchanti, A. | en |
| dc.contributor.author | Sideris, D. A. | en |
| dc.date.accessioned | 2015-11-24T19:16:24Z | - |
| dc.date.available | 2015-11-24T19:16:24Z | - |
| dc.identifier.issn | 1522-1865 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21658 | - |
| dc.rights | Default Licence | - |
| dc.subject | *Angioplasty, Balloon | en |
| dc.subject | Animals | en |
| dc.subject | Arterial Occlusive Diseases/etiology | en |
| dc.subject | Disease Models, Animal | en |
| dc.subject | Dose-Response Relationship, Radiation | en |
| dc.subject | Femoral Artery/*radiation effects/*surgery | en |
| dc.subject | Hypercholesterolemia/complications/*therapy | en |
| dc.subject | Male | en |
| dc.subject | Postoperative Complications/etiology | en |
| dc.subject | Rabbits | en |
| dc.subject | Radiotherapy Dosage | en |
| dc.subject | Time Factors | en |
| dc.subject | Treatment Outcome | en |
| dc.subject | Tunica Intima/radiation effects/surgery | en |
| dc.subject | Tunica Media/radiation effects/surgery | en |
| dc.subject | *X-Ray Therapy | en |
| dc.title | External beam irradiation in angioplasted arteries of hypercholesterolemic rabbits. The dose and time effect | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/12479912 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S1522186502001439/1-s2.0-S1522186502001439-main.pdf?_tid=2b7c9935c7e7078341b3fc66d45956c3&acdnat=1337844416_1bc327c02bda6c780a459948ab02e940 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2002 | - |
| heal.abstract | PURPOSE: To study the dose and time effect of external beam irradiation on the morphometry of both angioplasted and nonangioplasted arteries in a hypercholesterolemic rabbit model. METHODS AND MATERIALS: Eight groups of rabbit femoral arteries were studied: arteries (a) with no intervention, (b) irradiated with a 12-Gy 6 MV X-ray dose, (c) with a 18-Gy, (d) treated with balloon angioplasty, (e) dosed with 12-Gy half an hour post-angioplasty, (f) dosed with 18-Gy half an hour post-angioplasty, (g) dosed with 12-Gy 48 h post angioplasty, (g) dosed with 18-Gy 48 h post angioplasty. RESULTS: External irradiation at either 12 or 18 Gy was not found to change vessel morphometry in noninjured arteries. The 12-Gy dose given soon after angioplasty further increased percentage stenosis (63% on the average), despite the preservation of the lumen cross-sectional area. Positive remodeling was not observed in arteries given 18-Gy half an hour post angioplasty to counterbalance the increased neointimal formation. Therefore, this treatment resulted in a drastic reduction in lumen area and in enhancement of percentage stenosis (84% on the average). On the contrary, the delayed irradiation of the angioplasted arteries at either 12 or 18 Gy was not found to influence any of the studied morphometric parameters 5 weeks after angioplasty. CONCLUSIONS: Uniform external beam irradiation up to 18 Gy was well tolerated by intact femoral arteries. Prompt 12- or 18-Gy irradiations accentuated percentage stenosis. However the lumen cross-sectional area was preserved only at the lower dose point. Delayed irradiation at any dose did not influence the restenosis process. | en |
| heal.journalName | Cardiovasc Radiat Med | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kalef-Ezra-2002-External beam irradi.pdf | 272.78 kB | Adobe PDF | View/Open Request a copy |
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