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DC Field | Value | Language |
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dc.contributor.author | Giambona, A. | en |
dc.contributor.author | Makrydimas, G. | en |
dc.contributor.author | Leto, F. | en |
dc.contributor.author | Damiani, G. | en |
dc.contributor.author | Jakil, M. C. | en |
dc.contributor.author | Picciotto, F. | en |
dc.contributor.author | Renda, D. | en |
dc.contributor.author | Fiorino, R. | en |
dc.contributor.author | Renda, M. C. | en |
dc.contributor.author | Schillaci, G. | en |
dc.contributor.author | Gueli-Alletti, D. | en |
dc.contributor.author | Nicolaides, K. H. | en |
dc.contributor.author | Maggio, A. | en |
dc.date.accessioned | 2015-11-24T19:16:05Z | - |
dc.date.available | 2015-11-24T19:16:05Z | - |
dc.identifier.issn | 1365-2141 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21613 | - |
dc.rights | Default Licence | - |
dc.title | Feasibility of DNA diagnosis of haemoglobinopathies on coelocentesis | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.primary | 10.1111/j.1365-2141.2011.08621.x | - |
heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21385172 | - |
heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1111/j.1365-2141.2011.08621.x/asset/j.1365-2141.2011.08621.x.pdf?v=1&t=h0l47mne&s=63bebf5cfaadae1e8ff96624cd4b5b795cb3c7e7 | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
heal.publicationDate | 2011 | - |
heal.abstract | At 5-12 weeks of gestation the amniotic sac is surrounded by celomic fluid, which contains cells of fetal origin. This fluid can be sampled by celocentesis, which involves the ultrasound-guided insertion of a needle through the vagina. The aim of this study was to examine the feasibility of prenatal diagnosis of haemoglobinopathies from the celomic fluid using a specific protocol. Celocentesis was performed at 7-9 weeks gestation in 26 singleton pregnancies at risk for haemoglobinopathies. In 25 cases more than 30 fetal cells were recovered from the celomic fluid and in all these cases molecular analysis for haemoglobinopathies was possible and the results were confirmed by subsequent chorionic villus sampling or amniocentesis. The results of this study suggest that reliable diagnosis of thalassemia syndromes can be performed from 7 weeks gestation by celocentesis. Further work is necessary to demonstrate the safety of celocentesis before widespread use. | en |
heal.journalName | Br J Haematol | en |
heal.journalType | peer-reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ |
Files in This Item:
File | Description | Size | Format | |
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Giambona-2011-Feasibility of DNA d.pdf | 280.64 kB | Adobe PDF | View/Open Request a copy |
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