Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/21545Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Fotsis, T. | en |
| dc.contributor.author | Pepper, M. S. | en |
| dc.contributor.author | Aktas, E. | en |
| dc.contributor.author | Breit, S. | en |
| dc.contributor.author | Rasku, S. | en |
| dc.contributor.author | Adlercreutz, H. | en |
| dc.contributor.author | Wahala, K. | en |
| dc.contributor.author | Montesano, R. | en |
| dc.contributor.author | Schweigerer, L. | en |
| dc.date.accessioned | 2015-11-24T19:15:42Z | - |
| dc.date.available | 2015-11-24T19:15:42Z | - |
| dc.identifier.issn | 0008-5472 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21545 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Anticarcinogenic Agents/*pharmacology | en |
| dc.subject | Cattle | en |
| dc.subject | Cell Division/drug effects | en |
| dc.subject | Cells, Cultured | en |
| dc.subject | Endothelium, Vascular/cytology/drug effects | en |
| dc.subject | Fibroblast Growth Factor 2/pharmacology | en |
| dc.subject | Flavonoids/*pharmacology | en |
| dc.subject | Humans | en |
| dc.subject | Mitosis/drug effects | en |
| dc.subject | Neovascularization, Pathologic/*prevention & control | en |
| dc.title | Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/9230201 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1997 | - |
| heal.abstract | Consumption of a plant-based diet can prevent the development and progression of chronic diseases associated with extensive neovascularization, including solid malignant tumors. In previous studies, we have shown that the plant-derived isoflavonoid genistein is a potent inhibitor of cell proliferation and in vitro angiogenesis. In the present study, we report that certain structurally related flavonoids are more potent inhibitors than genistein. Indeed, 3-hydroxyflavone, 3',4'-dihydroxyflavone, 2',3'-dihydroxyflavone, fisetin, apigenin, and luteolin inhibited the proliferation of normal and tumor cells, as well as in vitro angiogenesis, at half-maximal concentrations in the low micromolar range. We have previously demonstrated that genistein concentrations in the urine of subjects consuming a plant-based diet is 30-fold higher than in subjects consuming a traditional Western diet. The wider distribution and the more abundant presence of flavonoids in the plant kingdom, together with the present results, suggest that flavonoids may contribute to the preventive effect of a plant-based diet on chronic diseases, including solid tumors. | en |
| heal.journalName | Cancer Res | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
There are no files associated with this item.
This item is licensed under a Creative Commons License
