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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Talbot, J. A. | en |
| dc.contributor.author | Lambert, A. | en |
| dc.contributor.author | Mitchell, R. | en |
| dc.contributor.author | Grabinski, M. | en |
| dc.contributor.author | Anderson, D. C. | en |
| dc.contributor.author | Tsatsoulis, A. | en |
| dc.contributor.author | Shalet, S. M. | en |
| dc.contributor.author | Robertson, W. R. | en |
| dc.date.accessioned | 2015-11-24T19:15:31Z | - |
| dc.date.available | 2015-11-24T19:15:31Z | - |
| dc.identifier.issn | 0001-5598 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21528 | - |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Bucladesine/pharmacology | en |
| dc.subject | Calcimycin/pharmacology | en |
| dc.subject | Calcium/pharmacology | en |
| dc.subject | Cells, Cultured | en |
| dc.subject | Dose-Response Relationship, Drug | en |
| dc.subject | Drug Interactions | en |
| dc.subject | Egtazic Acid/pharmacology | en |
| dc.subject | Estradiol/biosynthesis | en |
| dc.subject | Estrogens/*secretion | en |
| dc.subject | Follicle Stimulating Hormone/*pharmacology | en |
| dc.subject | Forskolin/pharmacology | en |
| dc.subject | Ionomycin/pharmacology | en |
| dc.subject | Male | en |
| dc.subject | Radioimmunoassay | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Inbred Strains | en |
| dc.subject | Sertoli Cells/*secretion | en |
| dc.title | Follicle-stimulating hormone-dependent estrogen secretion by rat Sertoli cells in vitro: modulation by calcium | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/1659097 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1991 | - |
| heal.abstract | We have investigated the role of Ca2+ in the control of FSH-induced estradiol secretion by Sertoli cells isolated from 8-10 days old rats. Exogenous Ca2+ (4-8 mmol/l) inhibited FSH-stimulated E2 secretion such that, with 8 mmol/l Ca2+ and FSH (8 IU/l) E2 secretion decreased from 2091 +/- 322 to 1480 +/- 84 pmol/l (p less than 0.002), whilst chelation of Ca2+ in the culture medium with EGTA (3 mmol/l) increased E2 secretion from 360 +/- 45 to 1242 +/- 133 pmol/l) in the absence of FSH. Further, EGTA (3 mmol/l) markedly potentiated FSH (8 IU/l), forskolin (1 mumol/l) and dibutyryl cAMP (1 mmol/l)-stimulated E2 secretion. Addition of the Ca2+ ionophores, ionomycin (2-5 mumol/l) and A23187 (2 mumol/l), inhibited FSH (8 IU/l)-stimulated E2 secretion by greater than 80%. The effect of ionomycin was totally reversible, whereas that of A23187 was irreversible. Ionomycin (5 mumol/l) had no effect on EGTA-induced E2 secretion in the absence of FSH, but reduced EGTA-provoked E2 secretion by 59% in the presence of FSH (8 IU/l). Similarly, forskolin- and dibutyryl cAMP-provoked E2 production was inhibited 46-50% by ionomycin (5 mumol/l). We conclude that FSH-induced E2 secretion from immature rat Sertoli cells is modulated by intra- and extracellular Ca2+. | en |
| heal.journalName | Acta Endocrinol (Copenh) | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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