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  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21420
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dc.contributor.authorVrtala, S.en
dc.contributor.authorHirtenlehner, K.en
dc.contributor.authorSusani, M.en
dc.contributor.authorAkdis, M.en
dc.contributor.authorKussebi, F.en
dc.contributor.authorAkdis, C. A.en
dc.contributor.authorBlaser, K.en
dc.contributor.authorHufnagl, P.en
dc.contributor.authorBinder, B. R.en
dc.contributor.authorPolitou, A.en
dc.contributor.authorPastore, A.en
dc.contributor.authorVangelista, L.en
dc.contributor.authorSperr, W. R.en
dc.contributor.authorSemper, H.en
dc.contributor.authorValent, P.en
dc.contributor.authorEbner, C.en
dc.contributor.authorKraft, D.en
dc.contributor.authorValenta, R.en
dc.date.accessioned2015-11-24T19:14:56Z-
dc.date.available2015-11-24T19:14:56Z-
dc.identifier.issn0892-6638-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21420-
dc.rightsDefault Licence-
dc.subjectAllergens/genetics/*immunologyen
dc.subjectAntigens, Planten
dc.subjectCell Divisionen
dc.subjectCells, Cultureden
dc.subjectCytokines/metabolismen
dc.subjectEpitopes, B-Lymphocyte/immunologyen
dc.subjectEpitopes, T-Lymphocyte/immunologyen
dc.subjectGenetic Engineeringen
dc.subjectHumansen
dc.subjectImmunoglobulin E/immunologyen
dc.subjectImmunoglobulin G/immunologyen
dc.subjectPlant Proteins/genetics/*immunologyen
dc.subjectRecombinant Proteins/genetics/immunologyen
dc.subjectT-Lymphocytes/cytology/*immunologyen
dc.subjectTh1 Cells/immunologyen
dc.titleGenetic engineering of a hypoallergenic trimer of the major birch pollen allergen Bet v 1en
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1096/fj.00-0767fje-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11511511-
heal.identifier.secondaryhttp://www.fasebj.org/content/early/2001/09/02/fj.00-0767fje.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2001-
heal.abstractAn estimated 100 million individuals suffer from birch pollen allergy. Specific immunotherapy, the only curative allergy treatment, can cause life-threatening anaphylactic side effects. Here, we report the genetic engineering of a recombinant trimer consisting of three covalently linked copies of the major birch pollen allergen, Bet v 1. The trimer exhibited profoundly reduced allergenic activity but contained similar secondary structures such as Bet v 1 wild type, Bet v 1-specific B cell and T-cell epitopes, and induced Th1 cytokine release. As immunogen, rBet v 1 trimer induced IgG antibodies, which blocked patients' IgE binding to Bet v 1 and related allergens. Thus, rBet v 1 trimer represents a novel hypoallergenic vaccine prototype for treatment of one of the most frequent allergy forms.en
heal.journalNameFaseb Journalen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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