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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21414
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dc.contributor.authorMiltiadous, G.en
dc.contributor.authorHatzivassiliou, M.en
dc.contributor.authorBashiardes, E.en
dc.contributor.authorBairaktari, E.en
dc.contributor.authorCariolou, M. A.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T19:14:54Z-
dc.date.available2015-11-24T19:14:54Z-
dc.identifier.issn0009-9163-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21414-
dc.rightsDefault Licence-
dc.subjectApolipoproteins A/*geneticsen
dc.subjectApolipoproteins Een
dc.subjectCarrier Proteins/geneticsen
dc.subjectCholesterol Ester Transfer Proteinsen
dc.subjectFemaleen
dc.subject*Glycoproteinsen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectHyperlipidemias/geneticsen
dc.subjectLipids/*blooden
dc.subjectLipoproteins/*blooden
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPolymorphism, Geneticen
dc.titleGenetic polymorphisms of the apolipoprotein A-IV in a Greek population and their relation to plasma lipid and lipoprotein levelsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12220435-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1034/j.1399-0004.2002.620304.x/asset/j.1399-0004.2002.620304.x.pdf?v=1&t=h0m8wugs&s=43a5041d24c6d2c1d17cf2049b082b8d735db19d-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2002-
heal.abstractApolipoprotein (apo) A-IV is a protein component of triglyceride-rich lipoproteins and high-density lipoproteins (HDL). In this study, two common genetic polymorphisms of the apoA-IV gene [codons 347(allele A and T) and 360 (allele 1 and 2)] were investigated in Greek patients with hyperlipidaemia and in healthy individuals matched for age, sex and smoking habits. In both study populations we evaluated the effect of these polymorphic sites on lipid and lipoprotein plasma levels and the body mass index (BMI). The frequencies of the 1/1 and 1/2 genotypes in codon 360 were 0.94 and 0.06 in hyperlipidemic patients and 0.92 and 0.08 in the control population, respectively. The frequencies of the A/A, A/T and T/T genotypes in codon 347 were 0.62, 0.34 and 0.04 in hyperlipidemic patients and 0.59, 0.33 and 0.08 in the control population, respectively. None of the above genotype frequency differences between the study populations reached statistical significance. The control population was not affected by any polymorphism of the apo A-IV gene. Hyperlipidaemic patients, carriers of the allele 2 (1/2 genotype), had significantly lower plasma triglyceride levels than carriers of the allele 1 (p = 0.03). Genetic variation in codon 347 had no influence on lipid and lipoprotein plasma levels. None of the polymorphisms at codons 360 and 347 affected the BMI. In conclusion, this study describes for the first time the genotype frequencies for polymorphic sites in codons 360 and 347 of the apo A-IV gene in a Greek population and suggests that the presence of the allele 2 is associated with lower plasma triglyceride levels in hyperlipidaemic patients.en
heal.journalNameClin Geneten
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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