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dc.contributor.authorEhret, G. B.en
dc.contributor.authorMunroe, P. B.en
dc.contributor.authorRice, K. M.en
dc.contributor.authorBochud, M.en
dc.contributor.authorJohnson, A. D.en
dc.contributor.authorChasman, D. I.en
dc.contributor.authorSmith, A. V.en
dc.contributor.authorTobin, M. D.en
dc.contributor.authorVerwoert, G. C.en
dc.contributor.authorHwang, S. J.en
dc.contributor.authorPihur, V.en
dc.contributor.authorVollenweider, P.en
dc.contributor.authorO'Reilly, P. F.en
dc.contributor.authorAmin, N.en
dc.contributor.authorBragg-Gresham, J. L.en
dc.contributor.authorTeumer, A.en
dc.contributor.authorGlazer, N. L.en
dc.contributor.authorLauner, L.en
dc.contributor.authorZhao, J. H.en
dc.contributor.authorAulchenko, Y.en
dc.contributor.authorHeath, S.en
dc.contributor.authorSober, S.en
dc.contributor.authorParsa, A.en
dc.contributor.authorLuan, J.en
dc.contributor.authorArora, P.en
dc.contributor.authorDehghan, A.en
dc.contributor.authorZhang, F.en
dc.contributor.authorLucas, G.en
dc.contributor.authorHicks, A. A.en
dc.contributor.authorJackson, A. U.en
dc.contributor.authorPeden, J. F.en
dc.contributor.authorTanaka, T.en
dc.contributor.authorWild, S. H.en
dc.contributor.authorRudan, I.en
dc.contributor.authorIgl, W.en
dc.contributor.authorMilaneschi, Y.en
dc.contributor.authorParker, A. N.en
dc.contributor.authorFava, C.en
dc.contributor.authorChambers, J. C.en
dc.contributor.authorFox, E. R.en
dc.contributor.authorKumari, M.en
dc.contributor.authorGo, M. J.en
dc.contributor.authorvan der Harst, P.en
dc.contributor.authorKao, W. H.en
dc.contributor.authorSjogren, M.en
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dc.contributor.authorAlexander, M.en
dc.contributor.authorTabara, Y.en
dc.contributor.authorShaw-Hawkins, S.en
dc.contributor.authorWhincup, P. H.en
dc.contributor.authorLiu, Y.en
dc.contributor.authorShi, G.en
dc.contributor.authorKuusisto, J.en
dc.contributor.authorTayo, B.en
dc.contributor.authorSeielstad, M.en
dc.contributor.authorSim, X.en
dc.contributor.authorNguyen, K. D.en
dc.contributor.authorLehtimaki, T.en
dc.contributor.authorMatullo, G.en
dc.contributor.authorWu, Y.en
dc.contributor.authorGaunt, T. R.en
dc.contributor.authorOnland-Moret, N. C.en
dc.contributor.authorCooper, M. N.en
dc.contributor.authorPlatou, C. G.en
dc.contributor.authorOrg, E.en
dc.contributor.authorHardy, R.en
dc.contributor.authorDahgam, S.en
dc.contributor.authorPalmen, J.en
dc.contributor.authorVitart, V.en
dc.contributor.authorBraund, P. S.en
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dc.contributor.authorUiterwaal, C. S.en
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dc.contributor.authorPalmas, W.en
dc.contributor.authorCampbell, H.en
dc.contributor.authorLudwig, B.en
dc.contributor.authorTomaszewski, M.en
dc.contributor.authorTzoulaki, I.en
dc.contributor.authorPalmer, N. D.en
dc.contributor.authorAspelund, T.en
dc.contributor.authorGarcia, M.en
dc.contributor.authorChang, Y. P.en
dc.contributor.authorO'Connell, J. R.en
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dc.contributor.authorHernandez, D.en
dc.contributor.authorNajjar, S.en
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dc.contributor.authorBrown, M. J.en
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dc.contributor.authorHingorani, A. D.en
dc.contributor.authorDay, I. N.en
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dc.contributor.authorBeilby, J. P.en
dc.contributor.authorLawrence, R. W.en
dc.contributor.authorClarke, R.en
dc.contributor.authorHopewell, J. C.en
dc.contributor.authorOngen, H.en
dc.contributor.authorDreisbach, A. W.en
dc.contributor.authorLi, Y.en
dc.contributor.authorYoung, J. H.en
dc.contributor.authorBis, J. C.en
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dc.contributor.authorViikari, J.en
dc.contributor.authorAdair, L. S.en
dc.contributor.authorLee, N. R.en
dc.contributor.authorChen, M. H.en
dc.contributor.authorOlden, M.en
dc.contributor.authorPattaro, C.en
dc.contributor.authorBolton, J. A.en
dc.contributor.authorKottgen, A.en
dc.contributor.authorBergmann, S.en
dc.contributor.authorMooser, V.en
dc.contributor.authorChaturvedi, N.en
dc.contributor.authorFrayling, T. M.en
dc.contributor.authorIslam, M.en
dc.contributor.authorJafar, T. H.en
dc.contributor.authorErdmann, J.en
dc.contributor.authorKulkarni, S. R.en
dc.contributor.authorBornstein, S. R.en
dc.contributor.authorGrassler, J.en
dc.contributor.authorGroop, L.en
dc.contributor.authorVoight, B. F.en
dc.contributor.authorKettunen, J.en
dc.contributor.authorHoward, P.en
dc.contributor.authorTaylor, A.en
dc.contributor.authorGuarrera, S.en
dc.contributor.authorRicceri, F.en
dc.contributor.authorEmilsson, V.en
dc.contributor.authorPlump, A.en
dc.contributor.authorBarroso, I.en
dc.contributor.authorKhaw, K. T.en
dc.contributor.authorWeder, A. B.en
dc.contributor.authorHunt, S. C.en
dc.contributor.authorSun, Y. V.en
dc.contributor.authorBergman, R. N.en
dc.contributor.authorCollins, F. S.en
dc.contributor.authorBonnycastle, L. L.en
dc.contributor.authorScott, L. J.en
dc.contributor.authorStringham, H. M.en
dc.contributor.authorPeltonen, L.en
dc.contributor.authorPerola, M.en
dc.contributor.authorVartiainen, E.en
dc.contributor.authorBrand, S. M.en
dc.contributor.authorStaessen, J. A.en
dc.contributor.authorWang, T. J.en
dc.contributor.authorBurton, P. R.en
dc.contributor.authorArtigas, M. S.en
dc.contributor.authorDong, Y.en
dc.contributor.authorSnieder, H.en
dc.contributor.authorWang, X.en
dc.contributor.authorZhu, H.en
dc.contributor.authorLohman, K. K.en
dc.contributor.authorRudock, M. E.en
dc.contributor.authorHeckbert, S. R.en
dc.contributor.authorSmith, N. L.en
dc.contributor.authorWiggins, K. L.en
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dc.contributor.authorShriner, D.en
dc.contributor.authorVeldre, G.en
dc.contributor.authorViigimaa, M.en
dc.contributor.authorKinra, S.en
dc.contributor.authorPrabhakaran, D.en
dc.contributor.authorTripathy, V.en
dc.contributor.authorLangefeld, C. D.en
dc.contributor.authorRosengren, A.en
dc.contributor.authorThelle, D. S.en
dc.contributor.authorCorsi, A. M.en
dc.contributor.authorSingleton, A.en
dc.contributor.authorForrester, T.en
dc.contributor.authorHilton, G.en
dc.contributor.authorMcKenzie, C. A.en
dc.contributor.authorSalako, T.en
dc.contributor.authorIwai, N.en
dc.contributor.authorKita, Y.en
dc.contributor.authorOgihara, T.en
dc.contributor.authorOhkubo, T.en
dc.contributor.authorOkamura, T.en
dc.contributor.authorUeshima, H.en
dc.contributor.authorUmemura, S.en
dc.contributor.authorEyheramendy, S.en
dc.contributor.authorMeitinger, T.en
dc.contributor.authorWichmann, H. E.en
dc.contributor.authorCho, Y. S.en
dc.contributor.authorKim, H. L.en
dc.contributor.authorLee, J. Y.en
dc.contributor.authorScott, J.en
dc.contributor.authorSehmi, J. S.en
dc.contributor.authorZhang, W.en
dc.contributor.authorHedblad, B.en
dc.contributor.authorNilsson, P.en
dc.contributor.authorSmith, G. D.en
dc.contributor.authorWong, A.en
dc.contributor.authorNarisu, N.en
dc.contributor.authorStancakova, A.en
dc.contributor.authorRaffel, L. J.en
dc.contributor.authorYao, J.en
dc.contributor.authorKathiresan, S.en
dc.contributor.authorO'Donnell, C. J.en
dc.contributor.authorSchwartz, S. M.en
dc.contributor.authorIkram, M. A.en
dc.contributor.authorLongstreth, W. T., Jr.en
dc.contributor.authorMosley, T. H.en
dc.contributor.authorSeshadri, S.en
dc.contributor.authorShrine, N. R.en
dc.contributor.authorWain, L. V.en
dc.contributor.authorMorken, M. A.en
dc.contributor.authorSwift, A. J.en
dc.contributor.authorLaitinen, J.en
dc.contributor.authorProkopenko, I.en
dc.contributor.authorZitting, P.en
dc.contributor.authorCooper, J. A.en
dc.contributor.authorHumphries, S. E.en
dc.contributor.authorDanesh, J.en
dc.contributor.authorRasheed, A.en
dc.contributor.authorGoel, A.en
dc.contributor.authorHamsten, A.en
dc.contributor.authorWatkins, H.en
dc.contributor.authorBakker, S. J.en
dc.contributor.authorvan Gilst, W. H.en
dc.contributor.authorJanipalli, C. S.en
dc.contributor.authorMani, K. R.en
dc.contributor.authorYajnik, C. S.en
dc.contributor.authorHofman, A.en
dc.contributor.authorMattace-Raso, F. U.en
dc.contributor.authorOostra, B. A.en
dc.contributor.authorDemirkan, A.en
dc.contributor.authorIsaacs, A.en
dc.contributor.authorRivadeneira, F.en
dc.contributor.authorLakatta, E. G.en
dc.contributor.authorOrru, M.en
dc.contributor.authorScuteri, A.en
dc.contributor.authorAla-Korpela, M.en
dc.contributor.authorKangas, A. J.en
dc.contributor.authorLyytikainen, L. P.en
dc.contributor.authorSoininen, P.en
dc.contributor.authorTukiainen, T.en
dc.contributor.authorWurtz, P.en
dc.contributor.authorOng, R. T.en
dc.contributor.authorDorr, M.en
dc.contributor.authorKroemer, H. K.en
dc.contributor.authorVolker, U.en
dc.contributor.authorVolzke, H.en
dc.contributor.authorGalan, P.en
dc.contributor.authorHercberg, S.en
dc.contributor.authorLathrop, M.en
dc.contributor.authorZelenika, D.en
dc.contributor.authorDeloukas, P.en
dc.contributor.authorMangino, M.en
dc.contributor.authorSpector, T. D.en
dc.contributor.authorZhai, G.en
dc.contributor.authorMeschia, J. F.en
dc.contributor.authorNalls, M. A.en
dc.contributor.authorSharma, P.en
dc.contributor.authorTerzic, J.en
dc.contributor.authorKumar, M. V.en
dc.contributor.authorDenniff, M.en
dc.contributor.authorZukowska-Szczechowska, E.en
dc.contributor.authorWagenknecht, L. E.en
dc.contributor.authorFowkes, F. G.en
dc.contributor.authorCharchar, F. J.en
dc.contributor.authorSchwarz, P. E.en
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dc.contributor.authorRotimi, C.en
dc.contributor.authorBots, M. L.en
dc.contributor.authorBrand, E.en
dc.contributor.authorSamani, N. J.en
dc.contributor.authorPolasek, O.en
dc.contributor.authorTalmud, P. J.en
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dc.contributor.authorKuh, D.en
dc.contributor.authorLaan, M.en
dc.contributor.authorHveem, K.en
dc.contributor.authorPalmer, L. J.en
dc.contributor.authorvan der Schouw, Y. T.en
dc.contributor.authorCasas, J. P.en
dc.contributor.authorMohlke, K. L.en
dc.contributor.authorVineis, P.en
dc.contributor.authorRaitakari, O.en
dc.contributor.authorGanesh, S. K.en
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dc.contributor.authorTai, E. S.en
dc.contributor.authorCooper, R. S.en
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dc.contributor.authorKooner, J. S.en
dc.contributor.authorMelander, O.en
dc.contributor.authorRidker, P. M.en
dc.contributor.authorBandinelli, S.en
dc.contributor.authorGyllensten, U. B.en
dc.contributor.authorWright, A. F.en
dc.contributor.authorWilson, J. F.en
dc.contributor.authorFerrucci, L.en
dc.contributor.authorFarrall, M.en
dc.contributor.authorTuomilehto, J.en
dc.contributor.authorPramstaller, P. P.en
dc.contributor.authorElosua, R.en
dc.contributor.authorSoranzo, N.en
dc.contributor.authorSijbrands, E. J.en
dc.contributor.authorAltshuler, D.en
dc.contributor.authorLoos, R. J.en
dc.contributor.authorShuldiner, A. R.en
dc.contributor.authorGieger, C.en
dc.contributor.authorMeneton, P.en
dc.contributor.authorUitterlinden, A. G.en
dc.contributor.authorWareham, N. J.en
dc.contributor.authorGudnason, V.en
dc.contributor.authorRotter, J. I.en
dc.contributor.authorRettig, R.en
dc.contributor.authorUda, M.en
dc.contributor.authorStrachan, D. P.en
dc.contributor.authorWitteman, J. C.en
dc.contributor.authorHartikainen, A. L.en
dc.contributor.authorBeckmann, J. S.en
dc.contributor.authorBoerwinkle, E.en
dc.contributor.authorVasan, R. S.en
dc.contributor.authorBoehnke, M.en
dc.contributor.authorLarson, M. G.en
dc.contributor.authorJarvelin, M. R.en
dc.contributor.authorPsaty, B. M.en
dc.contributor.authorAbecasis, G. R.en
dc.contributor.authorChakravarti, A.en
dc.contributor.authorElliott, P.en
dc.contributor.authorvan Duijn, C. M.en
dc.contributor.authorNewton-Cheh, C.en
dc.contributor.authorLevy, D.en
dc.contributor.authorCaulfield, M. J.en
dc.contributor.authorJohnson, T.en
dc.date.accessioned2015-11-24T19:14:53Z-
dc.date.available2015-11-24T19:14:53Z-
dc.identifier.issn1476-4687-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21409-
dc.rightsDefault Licence-
dc.subjectAfrica/ethnologyen
dc.subjectAsia/ethnologyen
dc.subjectBlood Pressure/*genetics/physiologyen
dc.subjectCardiovascular Diseases/*geneticsen
dc.subjectCoronary Artery Disease/geneticsen
dc.subjectEurope/ethnologyen
dc.subjectGenetic Predisposition to Disease/*geneticsen
dc.subjectGenome-Wide Association Studyen
dc.subjectHumansen
dc.subjectHypertension/geneticsen
dc.subjectKidney Diseases/geneticsen
dc.subjectPolymorphism, Single Nucleotide/*geneticsen
dc.subjectStroke/geneticsen
dc.titleGenetic variants in novel pathways influence blood pressure and cardiovascular disease risken
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1038/nature10405-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21909115-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2011-
heal.abstractBlood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>/=140 mm Hg systolic blood pressure or >/=90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.en
heal.journalNameNatureen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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