Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/21405Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ziogas, D. | en |
| dc.contributor.author | Roukos, D. H. | en |
| dc.date.accessioned | 2015-11-24T19:14:51Z | - |
| dc.date.available | 2015-11-24T19:14:51Z | - |
| dc.identifier.issn | 1534-4681 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21405 | - |
| dc.rights | Default Licence | - |
| dc.subject | Breast Neoplasms/*genetics/mortality/*surgery | en |
| dc.subject | Epigenesis, Genetic | en |
| dc.subject | Female | en |
| dc.subject | *Genomics | en |
| dc.subject | Humans | en |
| dc.subject | Neoplasm Recurrence, Local/*physiopathology | en |
| dc.title | Genetics and personal genomics for personalized breast cancer surgery: progress and challenges in research and clinical practice | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1245/s10434-009-0436-2 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19322611 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/v37650408315r523/fulltext.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2009 | - |
| heal.abstract | BACKGROUND: The age of personal genomics is here. A flood of translational research discoveries may influence also surgeon oncologist. Breast-conserving surgery (BCS) is standard care in early breast cancer. Classic clinicopathologic factors are suboptimal to predict risk of ipsilateral breast cancer (IBC) recurrence and/or contralateral breast cancer (CBC). Human genetic variation may be involved in local failures. OBJECTIVE: To describe the potential clinical utility of genetics, personal genomics, and epigenetics to identify IBC/CBC high-risk patients who might benefit from aggressive surgery (bilateral mastectomy). DATA SOURCES AND SYNTHESIS: PubMed (MEDLINE) was searched (January 1990 to November 2008). RESULTS: Even following current guidelines, IBC/CBC as isolated first event in a long-term aspect after treatment suggests a serious problem. Preclinical and clinical data reveal that at highest risk of IBC/CBC are patients with inherited BRCA1/2 mutations who benefited from bilateral mastectomy. Local failure risk prediction is currently unfeasible among familial non-BRCA1/2 (BRCA-test negative) and sporadic (no family history) breast cancer. Genome-wide association studies have already identified novel risk alleles with a series of tumor-initiating single-nucleotide polymorphisms (SNPs). Some of these variants and other novel SNPs and copy-number variants (CNVs) may also be relevant for local failures (IBC/CBC). CONCLUSIONS: Beyond established risk factors, genetic testing allows identification of high-risk patients (BRCA mutation carriers) who may benefit from bilateral mastectomy rather than BCS. Human genetic variation (SNPs/CNVs) and DNA methylation may be relevant for local failures assessment. Technological revolution has opened a new avenue but multiple challenges should be overcome to integrate SNPs/CNVs as markers for IBC/CBC risk-stratification-based personalized surgery. | en |
| heal.journalName | Ann Surg Oncol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Ziogas-2009-Genetics and persona.pdf | 262.55 kB | Adobe PDF | View/Open Request a copy |
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