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dc.contributor.authorFotsis, T.en
dc.contributor.authorPepper, M.en
dc.contributor.authorAdlercreutz, H.en
dc.contributor.authorFleischmann, G.en
dc.contributor.authorHase, T.en
dc.contributor.authorMontesano, R.en
dc.contributor.authorSchweigerer, L.en
dc.rightsDefault Licence-
dc.subjectAdrenal Cortex/blood supplyen
dc.subjectCell Division/drug effectsen
dc.subjectCells, Cultureden
dc.subjectCerebrovascular Circulationen
dc.subjectChromatography, Ion Exchangeen
dc.subjectClone Cellsen
dc.subject*Diet, Vegetarianen
dc.subjectEndothelium, Vascular/cytology/*drug effectsen
dc.subjectFibroblast Growth Factor 2/pharmacologyen
dc.subjectGas Chromatography-Mass Spectrometryen
dc.subjectGrowth Inhibitors/pharmacology/*urineen
dc.subjectIsoflavones/isolation & purification/*pharmacology/*urineen
dc.subjectMolecular Structureen
dc.subject*Neovascularization, Pathologicen
dc.titleGenistein, a dietary-derived inhibitor of in vitro angiogenesisen
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.abstractConsumption of a plant-based diet can prevent the development and progression of chronic diseases that are associated with extensive neovascularization; however, little is known about the mechanisms. To determine whether prevention might be associated with dietary-derived angiogenesis inhibitors, we have fractionated urine of healthy human subjects consuming a plant-based diet and examined the fractions for their abilities to inhibit the proliferation of vascular endothelial cells. Using gas chromatography-mass spectrometry, we showed that one of the most potent fractions contained several isoflavonoids, which we subsequently synthesized. Of all synthetic compounds, the isoflavonoid genistein was the most potent and inhibited endothelial cell proliferation and in vitro angiogenesis at concentrations giving half-maximal inhibition of 5 and 150 microM, respectively. As we have previously demonstrated, genistein concentrations in urine of subjects consuming a plant-based diet are in the micromolar range, while those of subjects consuming a traditional Western diet are lower by a factor of > 30. The high excretion of genistein in urine of vegetarians and our present results suggest that genistein may contribute to the preventive effect of a plant-based diet on chronic diseases, including solid tumors, by inhibiting neovascularization. Thus, genistein may represent a member of a new class of dietary-derived anti-angiogenic compounds.en
heal.journalNameProc Natl Acad Sci U S Aen
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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