1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21271
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTzoulaki, I.en
dc.contributor.authorMurray, G. D.en
dc.contributor.authorPrice, J. F.en
dc.contributor.authorSmith, F. B.en
dc.contributor.authorLee, A. J.en
dc.contributor.authorRumley, A.en
dc.contributor.authorLowe, G. D.en
dc.contributor.authorFowkes, F. G.en
dc.date.accessioned2015-11-24T19:14:14Z-
dc.date.available2015-11-24T19:14:14Z-
dc.identifier.issn0002-9262-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21271-
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectArteriosclerosis/*blood/physiopathologyen
dc.subjectC-Reactive Proteinen
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectFibrinogenen
dc.subject*Hemostasisen
dc.subjectHumansen
dc.subjectInflammation/*blood/physiopathologyen
dc.subjectInterleukin-6en
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPeripheral Vascular Diseases/*blood/physiopathologyen
dc.subjectPrognosisen
dc.subjectProspective Studiesen
dc.subjectQuestionnairesen
dc.subjectRisk Assessmenten
dc.subjectRisk Factorsen
dc.subjectTime Factorsen
dc.titleHemostatic factors, inflammatory markers, and progressive peripheral atherosclerosis: the Edinburgh Artery Studyen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1093/aje/kwj051-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16357107-
heal.identifier.secondaryhttp://aje.oxfordjournals.org/content/163/4/334.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2006-
heal.abstractThe interplay between inflammatory and hemostatic mechanisms may play a crucial role in the development and progression of atherosclerosis. The authors evaluated the separate and joint associations of hemostatic and inflammatory variables on peripheral atherosclerotic progression in the Edinburgh Artery Study, a population cohort study of 1,592 men and women aged 55-74 years that started in 1987. Levels of fibrinogen, fibrin D-dimer, von Willebrand factor, tissue plasminogen activator antigen, factor VII, prothrombin fragment 1 + 2, urinary fibrinopeptide A, C-reactive protein, and interleukin-6 were measured at baseline. Arm and ankle blood pressures were measured, and atherosclerotic progression was assessed by computing ankle brachial index (ABI) at baseline (1,582 participants) and after 12 years of follow-up (813 participants). Fibrinogen (p = 0.05) and D-dimer (p < or = 0.05) were significantly associated with ABI change independently of baseline ABI and cardiovascular disease risk factors. However, these associations were no longer significant when analyses were adjusted for either C-reactive protein or interleukin-6. Moreover, subjects with higher levels of both D-dimer and interleukin-6 at baseline had the greatest ABI decline. In conclusion, fibrinogen and D-dimer, but not other hemostatic factors, were associated with progressive peripheral atherosclerosis. Since D-dimer and fibrinogen are acute phase reactants, these data support the hypothesis that inflammation is more related to atherosclerosis than is hypercoagulation.en
heal.journalNameAm J Epidemiolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Show simple item record
Files in This Item:
File Description SizeFormat 
Tzoulaki-2006-Hemostatic factors.pdf102.45 kBAdobe PDFView/Open    Request a copy
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons