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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21270
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dc.contributor.authorWynne, H. A.en
dc.contributor.authorGoudevenos, J.en
dc.contributor.authorRawlins, M. D.en
dc.contributor.authorJames, O. F.en
dc.contributor.authorAdams, P. C.en
dc.contributor.authorWoodhouse, K. W.en
dc.date.accessioned2015-11-24T19:14:13Z-
dc.date.available2015-11-24T19:14:13Z-
dc.identifier.issn0306-5251-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21270-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAging/metabolismen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectIndocyanine Green/*pharmacokineticsen
dc.subjectLiver/blood supply/*metabolismen
dc.subjectMaleen
dc.subjectMetabolic Clearance Rateen
dc.subjectMiddle Ageden
dc.subjectRegional Blood Flowen
dc.subjectSpectrophotometry, Ultravioleten
dc.titleHepatic drug clearance: the effect of age using indocyanine green as a model compounden
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/2291878-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1990-
heal.abstractThe hepatic extraction ratio and clearance of indocyanine green (ICG) were determined and used to derive apparent liver blood flow in nine subjects between the ages of 22 and 83 years. There was no correlation between the hepatic extraction ratio of ICG and age (rs = -0.435, NS). There was a significant negative correlation between both ICG clearance and age (rs = -0.710, P less than 0.05) and apparent liver blood flow and age (rs = -0.750, P less than 0.05). These results validate the comparison of liver blood flow values derived from ICG clearance in humans over a wide age range and confirm that liver blood flow does fall with age.en
heal.journalNameBr J Clin Pharmacolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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