Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21249
Full metadata record
DC FieldValueLanguage
dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorLau, J.en
dc.date.accessioned2015-11-24T19:13:58Z-
dc.date.available2015-11-24T19:13:58Z-
dc.identifier.issn0002-9262-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21249-
dc.rightsDefault Licence-
dc.subjectAIDS-Related Opportunistic Infections/drug therapy/mortalityen
dc.subjectAcquired Immunodeficiency Syndrome/drug therapy/mortalityen
dc.subject*Algorithmsen
dc.subjectAnti-HIV Agents/administration & dosageen
dc.subjectBias (Epidemiology)en
dc.subjectDapsone/administration & dosageen
dc.subjectHumansen
dc.subjectMeta-Analysis as Topicen
dc.subjectModels, Statisticalen
dc.subjectOdds Ratioen
dc.subjectPentamidine/administration & dosageen
dc.subjectPneumonia, Pneumocystis/drug therapy/mortalityen
dc.subjectRandomized Controlled Trials as Topic/*statistics & numerical dataen
dc.subjectResearch Designen
dc.subjectRisken
dc.subjectSurvival Analysisen
dc.subjectTreatment Failureen
dc.subjectTrimethoprim-Sulfamethoxazole Combination/administration & dosageen
dc.titleHeterogeneity of the baseline risk within patient populations of clinical trials: a proposed evaluation algorithmen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9850135-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1998-
heal.abstractIn this paper, the authors present an evaluation algorithm for systematic assessment of the observed heterogeneity in disease risk within trial populations. Predictive models are used to estimate the predicted patient hazards, the odds of having an event in the upper risk quartile (ODU) and the lower risk quartile (ODL), and the odds ratio (rate ratio for time-to-event analyses) for having an event in the upper risk quartile versus the lower risk quartile (extreme quartile odds ratio (EQuOR) and extreme quartile rate ratio (EQuRR)). The ranges for these metrics depend on the extent to which predictors of the outcome of interest exist and are known and the extent to which data are collected in the trial, as well as on the eligibility criteria and the specific patients who are actually enrolled. ODU, ODL, and EQuOR values are used to systematically interpret the results for patients at different levels of risk, to evaluate generalizability, and to determine the need for subgroup analyses. Individual data for five outcomes from three trials (n = 842, 913, and 1,001, respectively) are used as examples. Observed EQuOR values ranged from 1.5 (very little predicted heterogeneity) to 59 (large heterogeneity). EQuRR values ranged from 2 to 46. ODU values ranged from 0.24 to 3.19 (generally high risk), and ODL values ranged from 0.01 (clinically negligible risk) to 0.16 (clinically meaningful risk). The algorithm may also be used for comparing diverse trials (e.g., in meta-analyses) and used prospectively for designing future trials, as shown in simulations.en
heal.journalNameAm J Epidemiolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Files in This Item:
There are no files associated with this item.


This item is licensed under a Creative Commons License Creative Commons