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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21227
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dc.contributor.authorDeretzi, G.en
dc.contributor.authorPelidou, S. H.en
dc.contributor.authorZou, L. P.en
dc.contributor.authorWei, L.en
dc.contributor.authorNennesmo, I.en
dc.contributor.authorZhu, J.en
dc.date.accessioned2015-11-24T19:13:48Z-
dc.date.available2015-11-24T19:13:48Z-
dc.identifier.issn1043-4666-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21227-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectDemyelinating Diseases/chemically induced/immunology/*pathologyen
dc.subjectHistocompatibility Antigens Class II/analysisen
dc.subjectInflammationen
dc.subjectInterleukin-4/*toxicityen
dc.subjectNerve Fibers/pathologyen
dc.subjectRatsen
dc.subjectRats, Inbred Lewen
dc.subjectRecombinant Proteins/*toxicityen
dc.subjectSciatic Nerve/drug effects/immunology/*pathologyen
dc.subjectTime Factorsen
dc.titleHigh inflammation and mild demyelination in the peripheral nervous system induced by an intraneural injection of RR interleukin-4en
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1006/cyto.1999.0613-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10843769-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1043466699906130/1-s2.0-S1043466699906130-main.pdf?_tid=b42eb74aff8542d58445be2c330811a5&acdnat=1332844608_f2d6ac1987f0a08f5c0a4cf954a35d4d-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2000-
heal.abstractTo examine the direct effects of IL-4 on peripheral nervous system (PNS) we injected recombinant rat IL-4 (rrIL-4) into the sciatic nerve of normal adult Lewis rats. Histopathological and immunohistochemical observations revealed that 1 day after injection, a large number of macrophages and MHC class II-positive cells appeared within both the perineurium and endoneurium. Only few CD4(+)and CD8(+)T cells existed in the endoneurium. From day 4 to day 7, we observed a gradual decline of inflammation, but the number of infiltrates in rrIL-4 injected nerves was significantly higher compared with sterile PBS-injected control group. On the contrary, demyelination affected significantly fewer nerve fibres in the rrIL-4-injected nerves compared with control group on day 7. Intraneural injection of rrIL-4 results in high grade inflammation and mild demyelination in the PNS.en
heal.journalNameCytokineen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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