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dc.contributor.authorTsouli, S.en
dc.contributor.authorKonitsiotis, S.en
dc.date.accessioned2015-11-24T19:13:08Z-
dc.date.available2015-11-24T19:13:08Z-
dc.identifier.issn1742-1241-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21158-
dc.rightsDefault Licence-
dc.subjectAntiparkinson Agents/*therapeutic useen
dc.subjectCatechol O-Methyltransferase/antagonists & inhibitorsen
dc.subjectDopamine Agonists/therapeutic useen
dc.subjectFood-Drug Interactionsen
dc.subjectHumansen
dc.subjectMonoamine Oxidase Inhibitors/therapeutic useen
dc.subjectParkinson Disease/*drug therapyen
dc.subjectPractice Guidelines as Topicen
dc.titleHow should we treat a patient with early Parkinson's disease?en
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1111/j.1742-1241.2010.02371.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20653797-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1742-1241.2010.02371.x/asset/j.1742-1241.2010.02371.x.pdf?v=1&t=h0aqq148&s=2f72d143583ba70bda8b859d85c0d4452906cc3d-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2010-
heal.abstractParkinson's disease (PD) is characterised by the progressive degeneration of dopaminergic nigro-striatal neurons and severe striatal dopaminergic deficiency, leading to bradykinesia. Levodopa was the first drug used for PD treatment and is still considered the most useful weapon for the control of PD symptoms. However, levodopa treatment induces motor complications, which is considered as a major problem as the disease progresses. Dopamine agonists, catechol-O-methyltransferase inhibitors and monoamine oxidase B inhibitors are some more recently developed drug categories which are expected to have a more favourable effect on motor complications. The choice of the best initial treatment in PD remains a controversial matter. Early therapeutic decisions in PD should balance the need for efficient short-term symptom control against long-term complication profile. The individualisation of the treatment seems to be the key for the best approach of early PD patients.en
heal.journalNameInt J Clin Practen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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