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https://olympias.lib.uoi.gr/jspui/handle/123456789/21129Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Marti-Carvajal, A. | en |
| dc.contributor.author | Salanti, G. | en |
| dc.contributor.author | Cardona, A. F. | en |
| dc.date.accessioned | 2015-11-24T19:12:53Z | - |
| dc.date.available | 2015-11-24T19:12:53Z | - |
| dc.identifier.issn | 1469-493X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21129 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Age Factors | en |
| dc.subject | Child | en |
| dc.subject | Hospital Mortality | en |
| dc.subject | Humans | en |
| dc.subject | Protein C/*therapeutic use | en |
| dc.subject | Randomized Controlled Trials as Topic | en |
| dc.subject | Recombinant Proteins/therapeutic use | en |
| dc.subject | Sepsis/*drug therapy/mortality | en |
| dc.subject | Shock, Septic/drug therapy/mortality | en |
| dc.title | Human recombinant activated protein C for severe sepsis | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1002/14651858.CD004388.pub3 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/18254048 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004388.pub3/abstract | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2008 | - |
| heal.abstract | BACKGROUND: Sepsis is a common, expensive and frequently fatal condition. There is an urgent need for developing new therapies to further reduce severe sepsis-induced mortality. One of those approaches is the use of human recombinant activated protein C (APC). OBJECTIVES: We assessed the clinical effectiveness of APC for the treatment of patients with severe sepsis or septic shock. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2005, Issue 2); MEDLINE (1966 to 2005); EMBASE (1980 to 2005) and LILACS (1982 to 2005). We contacted researchers and organizations working in the field. We did not have any language restriction. SELECTION CRITERIA: We included randomized controlled trials (RCTs) assessing the effects of APC for severe sepsis in adults and children. We excluded studies on neonates. DATA COLLECTION AND ANALYSIS: We independently performed study selection, quality assessment and data extraction. We estimated relative risks (RR) for dichotomous outcomes. We measured statistical heterogeneity using I-squared (I(2)). We used a random-effects model. MAIN RESULTS: We included four studies involving 4911 participants (4434 adults and 477 paediatric patients). For 28-day mortality, APC did not reduce the risk of death in adult participants with severe sepsis (pooled RR 0.92, 95% confidence interval (CI) 0.72 to 1.18; P = 0.50, I(2) = 72%). The effectiveness of APC did not seem to be associated with the degree of severity of sepsis (two studies): for an APACHE II score less than 25 the RR was 1.04 (95% CI 0.89 to 1.21; P = 0.70), and in participants with an APACHE II score of 25 or more the RR was 0.90 (95% CI 0.54 to 1.49; P = 0.68). APC use was, however, associated with a higher risk of bleeding (RR 1.48 (95% CI 1.07 to 2.06; P = 0.02, I(2) = 8%). Two studies were stopped early because there was little chance of reaching the efficacy endpoint by completion of the trial. AUTHORS' CONCLUSIONS: This updated review found no evidence suggesting that APC should be used for treating patients with severe sepsis or septic shock. Additionally, APC seems to be associated with a higher risk of bleeding. Unless additional RCTs provide evidence of a treatment effect, policy-makers, clinicians and academics should not promote the use of APC. | en |
| heal.journalName | Cochrane Database Syst Rev | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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