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  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21075
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dc.contributor.authorBairaktari, E. T.en
dc.contributor.authorKakafika, A. I.en
dc.contributor.authorPritsivelis, N.en
dc.contributor.authorHatzidimou, K. G.en
dc.contributor.authorTsianos, E. V.en
dc.contributor.authorSeferiadis, K. I.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T19:12:28Z-
dc.date.available2015-11-24T19:12:28Z-
dc.identifier.issn1523-6838-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21075-
dc.rightsDefault Licence-
dc.subjectBlood Glucose/analysisen
dc.subjectDiabetes Mellitus/blood/urineen
dc.subjectGlycosuria/epidemiologyen
dc.subjectHematologic Neoplasms/blood/urineen
dc.subjectHospital Departments/statistics & numerical dataen
dc.subjectHumansen
dc.subjectIncidenceen
dc.subjectInflammatory Bowel Diseases/urineen
dc.subjectInpatientsen
dc.subjectInternal Medicineen
dc.subjectJaundice, Obstructive/blood/urineen
dc.subjectKidney Tubules, Proximal/*physiopathologyen
dc.subjectLeptospirosis/urineen
dc.subjectPhosphates/urineen
dc.subjectPotassium/urineen
dc.subjectRetrospective Studiesen
dc.subjectUric Acid/*blood/urineen
dc.titleHypouricemia in individuals admitted to an inpatient hospital-based facilityen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12776275-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2003-
heal.abstractBACKGROUND: Decreased serum uric acid levels resulting from renal urate wasting occasionally are reported in hospitalized patients because of isolated or generalized proximal tubular damage. There are limited recent findings with regard to the incidence and cause of hypouricemia in patients admitted to an internal medicine clinic. The aim of this study is to examine the prevalence of hypouricemia in individuals admitted to our inpatient hospital-based facility and identify underlying causes and pathogenetic mechanisms and any association of hypouricemia and uricosuria with other tubular defects. METHODS: A total of 7,250 serum urate measurements were available on patients' admission. Hypouricemia is defined as a serum urate level less than 2.5 mg/dL (149 micromo/L). In all hypouricemic cases, a detailed clinical and laboratory investigation was performed. RESULTS: Hypouricemia was found in 90 patients (1.24%). In all except one patient, hypouricemia was associated with inappropriate uricosuria (urate fractional excretion [FE] > 10%; range, 10.8% to 94%). There was an inverse correlation between serum uric acid level and its FE (r = -0.73; P < 0.0001). The most common causes of hypouricemia were obstructive jaundice of any cause (n = 18), solid or hematologic neoplasias (n = 17), diabetes mellitus (n = 12), drugs affecting urate homeostasis (n = 10), and intracranial diseases (n = 8). Seventeen patients with hypouricemia showed one or more other manifestations of proximal tubular damage, such as glucosuria, inappropriate phosphaturia leading to hypophosphatemia, and kaliuria resulting in hypokalemia. CONCLUSION: Hypouricemia caused by inappropriate uricosuria is not rare in patients admitted to an internal medicine clinic, is related to underlying diseases, and may be associated with other abnormalities of proximal tubular function.en
heal.journalNameAm J Kidney Disen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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