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  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/21074
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dc.contributor.authorDouzinas, E. E.en
dc.contributor.authorKollias, S.en
dc.contributor.authorTiniakos, D.en
dc.contributor.authorEvangelou, E.en
dc.contributor.authorPapalois, A.en
dc.contributor.authorRapidis, A. D.en
dc.contributor.authorTsoukalas, G. D.en
dc.contributor.authorPatsouris, E.en
dc.contributor.authorRoussos, C.en
dc.date.accessioned2015-11-24T19:12:27Z-
dc.date.available2015-11-24T19:12:27Z-
dc.identifier.issn0090-3493-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21074-
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAnoxia/*complications/metabolismen
dc.subjectBiopsyen
dc.subjectBlood Gas Analysisen
dc.subject*Disease Models, Animalen
dc.subjectFluid Therapy/methodsen
dc.subjectIleum/*blood supply/pathologyen
dc.subjectInflammationen
dc.subjectInterleukin-1/blooden
dc.subjectIschemia/*therapyen
dc.subjectLung/pathologyen
dc.subjectMaleen
dc.subjectMesenteric Artery, Superioren
dc.subjectMultiple Organ Failure/etiology/pathology/prevention & controlen
dc.subjectOxygen/blooden
dc.subjectRandom Allocationen
dc.subjectReactive Oxygen Species/metabolismen
dc.subjectReperfusion/adverse effects/*methodsen
dc.subjectReperfusion Injury/*etiology/pathology/*prevention & controlen
dc.subjectSwineen
dc.subjectSystemic Inflammatory Response Syndrome/etiology/prevention & controlen
dc.subjectTime Factorsen
dc.subjectTreatment Outcomeen
dc.titleHypoxemic reperfusion after 120 mins of intestinal ischemia attenuates the histopathologic and inflammatory responseen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15640642-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2004-
heal.abstractOBJECTIVE: It has been suggested that reactive oxygen species play a pivotal role in the initial organ-tissue injury during reperfusion, eliciting inflammatory reaction and multiple organ failure. It was investigated if hypoxemic reperfusion attenuates tissue injury and inflammatory response. DESIGN: Randomized animal study. SETTING: Medical school laboratory. SUBJECTS: Twenty-five male pigs weighing 25-28 kg. INTERVENTIONS: Pigs were subjected to 120 mins of intestinal ischemia by clamping the superior mesenteric artery. Upon declamping, the animals were randomly assigned to receive either hypoxemic reperfusion (HR group, n = 9) reperfused with a Pao2 = 30-35 or normoxemic reperfusion (control group, n = 16) reperfused with a Pao2 = 100 mm Hg for 120 mins. Fluids without inotropes were given to combat circulatory shock during reperfusion. MEASUREMENTS AND MAIN RESULTS: Portal blood and intestinal and lung biopsies were collected at baseline, end of ischemia, and end of reperfusion. Histopathologic changes were scored, and interleukin-1beta, qualitative Limulus amebocyte, lysate test, and Pao2/Fio2 were measured. Eight of 16 animals of the control group and seven of nine of the HR group survived (p = .22). At the end of reperfusion, the intestinal (p = .004) and lung (p = .028) pathologic scores were lower in the HR group compared with controls. The only significant difference in concentration of interleukin-1beta in the portal blood between the two animal groups occurred 120 mins after reperfusion (p = .006). The number of HR animals with a positive Limulus test was significantly smaller compared with controls at 60 (p = .041) and 120 (p = .07) mins of reperfusion. During the period of ischemia, the Pao2/Fio2 decreased similarly in the control and HR group, whereas after 120 mins of reperfusion the rate was significantly higher in the HR group. CONCLUSIONS: Hypoxemic reperfusion represents an intervention that may attenuate the triggering of multifactorial cascade and organ tissue injury.en
heal.journalNameCrit Care Meden
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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