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https://olympias.lib.uoi.gr/jspui/handle/123456789/21072Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kyzas, P. A. | en |
| dc.contributor.author | Stefanou, D. | en |
| dc.contributor.author | Batistatou, A. | en |
| dc.contributor.author | Agnantis, N. J. | en |
| dc.date.accessioned | 2015-11-24T19:12:26Z | - |
| dc.date.available | 2015-11-24T19:12:26Z | - |
| dc.identifier.issn | 0304-3835 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21072 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Aged, 80 and over | en |
| dc.subject | Cell Hypoxia/*physiology | en |
| dc.subject | DNA-Binding Proteins/metabolism | en |
| dc.subject | Gene Expression Regulation, Neoplastic | en |
| dc.subject | Head and Neck Neoplasms/*blood supply/*metabolism/pathology | en |
| dc.subject | Humans | en |
| dc.subject | Hypoxia-Inducible Factor 1 | en |
| dc.subject | Hypoxia-Inducible Factor 1, alpha Subunit | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Middle Aged | en |
| dc.subject | Neovascularization, Pathologic/*metabolism | en |
| dc.subject | Nuclear Proteins/metabolism | en |
| dc.subject | Prognosis | en |
| dc.subject | Retrospective Studies | en |
| dc.subject | Survival Analysis | en |
| dc.subject | Transcription Factors/metabolism | en |
| dc.subject | Vascular Endothelial Growth Factor A/metabolism | en |
| dc.title | Hypoxia-induced tumor angiogenic pathway in head and neck cancer: an in vivo study | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1016/j.canlet.2004.11.060 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15978334 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0304383504009772/1-s2.0-S0304383504009772-main.pdf?_tid=3ee16a286f4c7c72baa0e75699f79c4e&acdnat=1333348283_3995d174a2a3a68b6009c7ecd9ce6c57 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2005 | - |
| heal.abstract | Numerous studies indicate the importance of hypoxia-induced pathway in tumor angiogenesis, but in vivo studies examining the importance of this mechanism in prognosis of patients with head and neck squamous cell carcinoma present conflicting results. We performed a retrospective analysis of 81 patients with head and neck squamous cell carcinoma in order to investigate whether hypoxia-inducible factor 1a (HIF-1a) immunohistochemical expression correlates with vascular endothelial growth factor (VEGF) expression and clinicopathologic parameters or prognosis. Our results showed a statistically significant association between HIF-1a and VEGF expression in tumors located in the lower lip and in larynx, but not in those located in the oral cavity. HIF-1a expression had no impact on prognosis, while VEGF expression correlated significantly with adverse prognosis. These findings support the hypothesis that tumor angiogenesis is close related, but not strictly dependent, on the hypoxic conditions of tumor's microenvironment. | en |
| heal.journalName | Cancer Lett | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kyzas-2005-Hypoxia-induced tumo.pdf | 254 kB | Adobe PDF | View/Open Request a copy |
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